Exon-1 Polymorphism of ctla-4 Gene in Iranian Patients with Graves' Disease

Kalantari, Tahereh; Mostafavi, Hamid; Pezeshki, Abdul Mohammad; Farjadian, Shirin; Doroudchi, Mehrnoosh; Yeganeh, Farshid; Ghaderi, Abbas

doi:10.1080/0891693032000114544

Cited by 21 publications

(17 citation statements)

References 25 publications

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“…The lowest ''G'' allele frequency (0.48) was noted in Caucasian GD population and among healthy individuals in Iranian (0.37) and Caucasian population (0.38) [9,12,22]. The present study shows that the ''G'' allele frequency is 0.63 among South Indian population (Madurai), which is comparable to that of the Taiwanese ''G'' allele frequency (0.67) [23].…”

Section: Resultsmentioning

confidence: 99%

A Study on the Level of T3, T4, TSH and the Association of A/G Polymorphism with CTLA-4 Gene in Graves’ Hyperthyroidism among South Indian Population

Veeramuthumari¹,

Isabel²,

Kannan

2010

Ind J Clin Biochem

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Graves' disease (GD) is an organ-specific heterogenous autoimmune disorder associated with T-lymphocyte abnormality affecting the thyroid, eyes and skin. GD is a multifactorial disease that develops as a result of complex interaction between genetic susceptibility genes and environmental factors. It has been suggested that the Cytotoxic T lymphocytes associated molecule-4 (CTLA-4) is a genetic susceptibility candidate for GD. The present study was focused on A/G polymorphism at position 49 in exon-1 of the CTLA-4 gene in 80 GD patients (GP) and 80 sex and age matched healthy individuals among South Indian (Madurai) population. Serum concentrations of thyroid hormone (T 4 , T 3 and TSH) were determined by using automated analyzer. The genomic DNA was isolated from the patient and control groups and genotyping was performed using the polymerase chain reaction followed by restriction enzyme analysis using Bbv1. Significant difference (P \ 0

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Section: Resultsmentioning

confidence: 99%

A Study on the Level of T3, T4, TSH and the Association of A/G Polymorphism with CTLA-4 Gene in Graves’ Hyperthyroidism among South Indian Population

Veeramuthumari¹,

Isabel²,

Kannan

2010

Ind J Clin Biochem

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“…No articles mentioned explicit blinding of the personnel that performed the genotyping. In three studies (two for A49G polymorphism and one for CT60), the distribution of genotypes in the control group deviated significantly from HWE (36,38,41).…”

Section: Eligible Studiesmentioning

confidence: 93%

“…Four teams were from Europe and six from Asia. Nine teams had already published data on A49G polymorphism (3,26,28,29,37,38,43,44,47), but only two on CT60 polymorphism (3,48). Three teams provided genotyping data from different cohorts than those previously published (29,38,48).…”

Section: Eligible Studiesmentioning

confidence: 94%

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Cytotoxic T-Lymphocyte Associated Antigen 4 Gene Polymorphisms and Autoimmune Thyroid Disease: A Meta-Analysis

Kavvoura

Akamizu

Awata

et al. 2007

The Journal of Clinical Endocrinology &Amp; Metabolism

168

129

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“…Previous studies reported that the highest ''G'' allele frequency (76%) was noted in Chinese GD population (Wang et al, 2004). The lowest ''G'' allele Science Publications AJBB frequency (48%) was noted in Caucasian GD population and among healthy individuals in Iranian (37%) (Kalantari et al, 2003) and Caucasian population (38%) (Bednarczuk et al, 2003). The study of Veeramuthumari et al (2011), shows that the ''G'' allele frequency is 63% among South Indian population, which is comparable to that of the Taiwanese ''G'' allele frequency (67%) (Weng et al, 2005) and Koreans (68%) (Park et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Ctla-4 Gene Polymorphism in Relation to Thyroid Disorders in Patients With Chronic Hepatitis C Under Interferon Alpha Therapy

El-Khair

Metwali

El-Maksoud

et al. 2012

American Journal of Biochemistry and Biotechnology

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Thyroid autoimmunity and dysfunction have reported as side effects of interferon-α treatment. The CT60 and exon 1+49 A/G polymorphisms in the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) gene have linked to susceptibility to autoimmune disease. The aim of this research was to analyze the frequencies of CTLA-4 CT60 and +49 A/G polymorphisms and evaluate both polymorphisms as indicators of thyroid disorder susceptibility in chronic HCV Egyptian patients under interferon therapy. This study was carried out on 114 chronic HCV patients under combined therapy of interferon-α and Ribavirin. From them, 60 chronic HCV patients without thyroid disorder were considered the control group. The other 54 patients were having thyroid disorder either hypothyroidism (N = 35) or Grave's Disease (GD) (N = 19). For all subjects, the genotypes of CTLA-4 gene CT60 and +49 A/G polymorphisms were studied using RFLP technique. For +49 A/G polymorphism, the genotypes frequencies in controls were: AA (30), AG (31.7) and GG (38.3%). Whereas, in hypothyroidism patients, the AA, AG and GG genotypes frequencies were (20), (57.1%) and (22.9%) respectively, while in grave's disease, the AA, AG and GG genotypes frequencies were (26.3 (57.9) and (15.8%) respectively. The AG genotype was significantly associated with thyroid disease. As regards CT60 polymorphism, the genotypes frequencies in controls were: CC (38.3), CT (35) and TT (26.7%). Whereas, in hypothyroidism patients, the CC, CT and TT genotypes frequencies were (60), (20) and (20%) respectively, while in grave's disease, the CC, CT and TT genotypes frequencies were (68.4), (15.8) and (15.8%) respectively. The CC genotype was significantly associated with thyroid disorders. CTLA-4 gene +49A/G and CT60 polymorphisms confer susceptibility to autoimmune thyroid disorder and confirm usefulness of CTLA-4 genotyping in predicting thyroid disorder in chronic HCV patients under interferon therapy.

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Exon-1 Polymorphism of ctla-4 Gene in Iranian Patients with Graves' Disease

Cited by 21 publications

References 25 publications

A Study on the Level of T3, T4, TSH and the Association of A/G Polymorphism with CTLA-4 Gene in Graves’ Hyperthyroidism among South Indian Population

A Study on the Level of T3, T4, TSH and the Association of A/G Polymorphism with CTLA-4 Gene in Graves’ Hyperthyroidism among South Indian Population

Cytotoxic T-Lymphocyte Associated Antigen 4 Gene Polymorphisms and Autoimmune Thyroid Disease: A Meta-Analysis

Ctla-4 Gene Polymorphism in Relation to Thyroid Disorders in Patients With Chronic Hepatitis C Under Interferon Alpha Therapy

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