Exophiala jeanselmei infection in a postrenal transplant patient

Relapsing Exophiala jeanselmei phaeohyphomycosis in a lung-transplant patient

“…The treatment of solid organ transplant patients with E. jeanselmei pheomycotic cyst/subcutaneous phaeohyphomycosis has been incision and drainage, and surgical excision with (2, 3, 8–10) or without antifungal therapy (11). Antifungal agents used include amphotericin B, itraconazole, ketoconazole or 5‐fluorocytosine (2, 3, 8–10). However, there have been no previous reports regarding the use of fluconazole for the treatment of an E. jeanselmei pheomycotic cyst / subcutaneous phaeohyphomycosis.…”

“…The duration of therapy for solid organ transplant patients with an E. jeanselmei pheomycotic cyst / subcutaneous phaeohyphomycosis has ranged from 6 weeks to 2 years (2, 3, 8–10). Four post‐kidney‐transplant patients and two post‐heart‐transplant patients (2, 3, 8–11) with pheomycotic cysts/subcutaneous phaeohyphomycosis due to E. jeanselmei did well upon the completion of therapy (Table 1). There was no attributable mortality due to localized E. jeanselmei subcutaneous phaeohyphomycosis reported in these solid organ transplant recipients.…”

Hyalohyphomycosis masquerading as squamous cell carcinoma

“…In the series of Ziefer and Connor (2), 9 of 25 patients were immunocompromised by various conditions including immunosuppressive therapy, infection with chronic debilitating disease, and malnutrition. Phaeohyphomycosis and hyalohyphomycosis have been reported in renal transplant patients (5), leukemia patients (7), in individuals receiving long-term prednisone therapy (11), and in patients with acquired immunodeficiency syndrome (AIDS) (8). In a case report (8), phaeophyphomycosis presented in an AIDS patient as multiple 1-to 3-mm pigmented papules on the scrotum that resembled seborrheic keratoses.…”

Phaeohyphomycosis from Exophiala jeanselmei with Concomitant Nocardia asteroides Infection in a Renal Transplant Recipient: Case Report and Review of the Literature

“…Many of these patients had localized infection, as did our patient (Table 1). 1,[5][6][7][8][9][10] Although the true frequency of Exophiala is not documented, case reports confirm its systemic and localized occurrence in other immunocompromised patients such as those with human immunodeficiency viral (HIV) disease and systemic lupus erythematosus. 9,10 Surgical excision or cryotherapy of E. jeanselmei may be considered first-line therapy, specifically if the lesions are small.…”