Exophytic papillary prostatic duct adenocarcinoma with endometrioid features, occurring in prostatic urethra after turp

Elgamal, Abdel-Aziz A.; Vandeursen, H.; Voorde, Wim Van de; Baert, Luc; Poppel, Hendrik Van; Lauweryns, Joseph M.

doi:10.1016/0090-4295(94)90202-x

Cited by 11 publications

(5 citation statements)

References 26 publications

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“…In addition, many of the ‘normal serum PSA’ tumours had extensive intraductal spread and ductal adenocarcinoma differentiation. It was shown previously that ductal prostatic carcinomas have less of an effect on serum PSA [22,23]. We are currently exploring factors to explain why serum PSA is not elevated in these men, including tumour location, pattern of invasion, and microvessel density (angiogenesis).…”

Section: Discussionmentioning

confidence: 99%

Characterizing prostatic adenocarcinomas in men with a serum prostate specific antigen level of <4.0 ng/mL

Sokoloff¹,

Yang

Fumo

et al. 2004

BJU International

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grading, and for the presence of PSA production. Tumours were classified as 'clinically insignificant' if the tumour volume was <0.5 mL and the Gleason score <7. RESULTSThe mean ( SD , range) preoperative PSA level was 3.04 (0.85, 0.8-3.8) ng/mL. Indications for biopsy included an abnormal digital rectal examination (61%), a PSA velocity of >0.75 ng/mL/year (12%), a strong family history of prostate cancer (3%), obstructive urinary symptoms (2%), or no obvious indication (23%). Thirty-eight (48%) tumours were clinically insignificant. Of 41 clinically significant cancers, 13 had a final Gleason score of ≥ 7, 20 had extraprostatic extension and 11 had a tumour volume of ≥ 10 mL. Of the 79 prostate cancer specimens 78 stained strongly for PSA; the exception was a Gleason 9 tumour. With a mean (range) follow-up of 3.5 (0.18-6) years only one patient had a biochemical recurrence (PSA ≥ 0.1 ng/mL). CONCLUSIONSMost prostate cancers in men with a PSA level of <4.0 ng/mL are clinically significant and PSA-producing. Many of these tumours are high-grade, high-volume and extraprostatic. We are currently exploring factors to explain why serum PSA is not elevated in these men, including tumour location, pattern of invasion and microvessel density.

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Section: Discussionmentioning

confidence: 99%

Characterizing prostatic adenocarcinomas in men with a serum prostate specific antigen level of <4.0 ng/mL

Sokoloff¹,

Yang

Fumo

et al. 2004

BJU International

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“…Tu et al17 reported that prognosis was comparable to other common types of prostate cancer in 25 cases of single histological type prostatic ductal adenocarcinoma, with an overall survival of 13.8 years. Some researchers believe that prognosis for prostatic ductal adenocarcinoma can be closely related to the clinical stage, tumor location, depth of invasion, and other prostate diseases 16,18,19. Prognosis of patients receiving different treatments were all excellent in our study, probably due to the low clinical staging and early diagnosis and treatment.…”

Section: Discussionmentioning

confidence: 99%

Ductal adenocarcinoma of the prostate: immunohistochemical findings and clinical significance

Sha

Jiang²,

Pan³

et al. 2013

OTT

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IntroductionTo investigate the clinical features, diagnosis, treatment, and prognosis of ductal adenocarcinoma of the prostate.MethodsThe clinicopathological and immunohistochemical data of seven patients with ductal adenocarcinoma of the prostate were retrospectively analyzed. All patients underwent physical examination, magnetic resonance imaging (MRI), bone scan, cystoscopy, and computed tomography (CT) scan. The level of prostate-specific antigen (PSA) before and after surgery was assessed. Different prostate cancer markers were used for immunohistochemical staining.ResultsThe mean age of the seven patients diagnosed with prostatic ductal adenocarcinoma in this study was 76.2 years (range 57–88). Five patients presented with intermittent and painless gross hematuria, one patient with progressive dysuria, and one patient with elevated serum PSA on routine health examination. The level of PSA before surgery ranged from 1.3 to 45.0 ng/mL. Immunohistochemical staining results of the prostatic ductal adenocarcinoma confirmed positivity for PSA, prostatic acid phosphatase, androgen receptor, and alpha-methyacyl co-enzyme A (CoA)-reductase markers. Two of the patients underwent bilateral orchiectomy combined with anti-androgen therapy, three underwent transurethral resection of prostate, one received radical prostatectomy, and one received medical castration therapy. The clinical outcomes of all patients were satisfactory, based on follow-up data. The symptoms of hematuria and dysuria were ameliorated well, and the postoperative PSA level decreased below 4.0 ng/mL. Recurrence or metastasis of disease was not detected on MRI and bone scan.ConclusionDuctal adenocarcinoma of the prostate is a rare subtype of prostate carcinoma, the diagnosis of which could be based on pathological and immunohistochemical examination. Earlier management promises better prognosis.

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“…Magnetic resonance imaging is able to differentiate this tumor from prostatic cancer that originates from the peripheral zone. Other malignant tumors can be excluded such as exophytic papillary prostatic duct adenocarcinoma [14], mucinous adenocarcinoma [15], and non-Hodgkin's lymphoma of the urethra [16] due to tumor characteristics.…”

Section: Discussionmentioning

confidence: 99%

MR findings of prostatic urethral polyp in an adult

Sugimura

Boku

et al. 2002

Eur Radiol

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We report MR imaging characteristics of a prostatic urethral polyp in a 35-year-old man. Traditionally, the methods of diagnosis include computed tomography, transrectal sonography, voiding cystourethrography, intravenous pyelography, urethroscopy, and cystoscopy. To our knowledge, MR findings have not been previously described. In this case, MR imaging clearly demonstrated a polypoid tumor located in the prostatic urethra with a stalk connected to the bladder neck. A pathological study revealed the polyp consisted of a fibrovascular core covered with a double layered, prostatic-type epithelium.

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Exophytic papillary prostatic duct adenocarcinoma with endometrioid features, occurring in prostatic urethra after turp

Cited by 11 publications

References 26 publications

Characterizing prostatic adenocarcinomas in men with a serum prostate specific antigen level of <4.0 ng/mL

Characterizing prostatic adenocarcinomas in men with a serum prostate specific antigen level of <4.0 ng/mL

Ductal adenocarcinoma of the prostate: immunohistochemical findings and clinical significance

MR findings of prostatic urethral polyp in an adult

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