EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis

Jamin, Soazik P.; Petit, Fabrice G.; Kervarrec, Christine; Smagulova, Fátima; Illner, Doris; Scherthan, Harry; Primig, Michael

doi:10.1038/s41598-017-14643-y

Cited by 26 publications

(28 citation statements)

References 65 publications

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“…The presence of exosome core subunits in the cytoplasm in the reproductive period, while LcRRP6 was detected in nuclei, suggests that LcRRP6 might have functions independent of the exosome. Confirming our results, hRRP6 has been suggested to have a specific role in RNA processing during the development of spermatogonia [20], and shown to localize to nucleoli of mouse spermatogonia, but become undetectable when cells enter spermiogenesis [21].…”

Section: Discussionsupporting

confidence: 89%

Differential expression of RNA exosome subunits in the amphibian Lithobates catesbeianus during reproductive and non-reproductive periods

et al. 2019

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ObjectiveThe RNA exosome is an evolutionarily conserved 3′–5′ exoribonucleolytic protein complex involved in processing and degradation of different classes of nuclear and cytoplasmic RNAs, and, therefore, important for the posttranscriptional control of gene expression. Despite the extensive in vivo functional studies and the structural data on the RNA exosome, few studies have been performed on the localization and expression of exosome subunits during gametogenesis, process during which gene expression is largely controlled at the posttranscriptional level.ResultsWe report the identification of exosome subunits in Lithobates catesbeianus and analysis of the differential subcellular localization of RNA exosome core and catalytic subunits in testis cells. In addition, we show seasonal differences in the expression levels of four exosome subunits in different organs. In addition to being part of the RNA exosome complex, its subunits might participate independently of the complex in the control of gene expression during seasonal variation in bullfrog tissues. These results may be relevant for other eukaryotic species.Electronic supplementary materialThe online version of this article (10.1186/s13104-019-4077-7) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 89%

Differential expression of RNA exosome subunits in the amphibian Lithobates catesbeianus during reproductive and non-reproductive periods

et al. 2019

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“…This noncanonical role of the NMD pathway could be important in other cells. The RNA exosome complex itself participates in spermatogenesis regulation, during which Exosc10 is dynamically expressed [93].…”

Section: Rna Surveillance During Tissue Developmentmentioning

confidence: 99%

Biology of RNA Surveillance in Development and Disease

Laffleur

Basu

2019

Trends in Cell Biology

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The ‘RNA world’, in which RNA molecules stored information and acquired enzymatic properties, has been proposed to have preceded organism life. RNA is now recognized for its central role in biology, with accumulating evidence implicating coding and noncoding (nc)RNAs in myriad mechanisms regulating cellular physiology and disequilibrium in transcriptomes resulting in pathological conditions. Nascently synthesized RNAs are subjected to stringent regulation by sophisticated RNA surveillance pathways. In this review, we integrate these pathways from a developmental viewpoint, proposing RNA surveillance as the convergence of mechanisms that ensure the exact titration of RNA molecules in a spatiotemporally controlled manner, leading to development without the onset of pathological conditions, including cancer.

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“…The second overlapping genomic region under positive selection in Yaroslavl, Kholmogor and Holstein breeds containing TNFRSF1B, MFN2, PLOD1, KIAA2013, NPPB, NPPA, CLCN6, MTHFR, AGTRAP, FBXO2, MTOR, ANGPTL7, EXOSC10, and MASP2 genes was found on BTA16 (Table 3, S6 Table). The selected candidate genes are involved in different biological processes in cattle, including milk production-MTHFR [103] and mTOR genes [104,105]; reproduction-PLOD1 [106], NPPA and NPPB [107], EXOSC10 genes [108]; immunity-TNFRSF1B [109] and MASP2 genes [110,111]; and metabolism-MFN2 gene [112].…”

Section: Plos Onementioning

confidence: 99%

Selection signatures in two oldest Russian native cattle breeds revealed using high-density single nucleotide polymorphism analysis

et al. 2020

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Native cattle breeds can carry specific signatures of selection reflecting their adaptation to the local environmental conditions and response to the breeding strategy used. In this study, we comprehensively analysed high-density single nucleotide polymorphism (SNP) genotypes to characterise the population structure and detect the selection signatures in Russian native Yaroslavl and Kholmogor dairy cattle breeds, which have been little influenced by introgression with transboundary breeds. Fifty-six samples of pedigree-recorded purebred animals, originating from different breeding farms and representing different sire lines, of the two studied breeds were genotyped using a genome-wide bovine genotyping array (Bovine HD BeadChip). Three statistical analyses—calculation of fixation index (FST) for each SNP for the comparison of the pairs of breeds, hapFLK analysis, and estimation of the runs of homozygosity (ROH) islands shared in more than 50% of animals—were combined for detecting the selection signatures in the genome of the studied cattle breeds. We confirmed nine and six known regions under putative selection in the genomes of Yaroslavl and Kholmogor cattle, respectively; the flanking positions of most of these regions were elucidated. Only two of the selected regions (localised on BTA 14 at 24.4–25.1 Mbp and on BTA 16 at 42.5–43.5 Mb) overlapped in Yaroslavl, Kholmogor and Holstein breeds. In addition, we detected three novel selection sweeps in the genome of Yaroslavl (BTA 4 at 4.74–5.36 Mbp, BTA 15 at 17.80–18.77 Mbp, and BTA 17 at 45.59–45.61 Mbp) and Kholmogor breeds (BTA 12 at 82.40–81.69 Mbp, BTA 15 at 16.04–16.62 Mbp, and BTA 18 at 0.19–1.46 Mbp) by using at least two of the above-mentioned methods. We expanded the list of candidate genes associated with the selected genomic regions and performed their functional annotation. We discussed the possible involvement of the identified candidate genes in artificial selection in connection with the origin and development of the breeds. Our findings on the Yaroslavl and Kholmogor breeds obtained using high-density SNP genotyping and three different statistical methods allowed the detection of novel putative genomic regions and candidate genes that might be under selection. These results might be useful for the sustainable development and conservation of these two oldest Russian native cattle breeds.

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EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis

Cited by 26 publications

References 65 publications

Differential expression of RNA exosome subunits in the amphibian Lithobates catesbeianus during reproductive and non-reproductive periods

Differential expression of RNA exosome subunits in the amphibian Lithobates catesbeianus during reproductive and non-reproductive periods

Biology of RNA Surveillance in Development and Disease

Selection signatures in two oldest Russian native cattle breeds revealed using high-density single nucleotide polymorphism analysis

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