Exosomal miRNAs in osteoarthritis

Mihanfar, Aynaz; Shakouri, Seyed Kazem; Khadem-Ansari, Mohammad Hassan; Fattahi, Amir; Latifi, Zeinab; Nejabati, Hamid Reza; Nouri, Mohammad

doi:10.1007/s11033-020-05443-1

Cited by 24 publications

(20 citation statements)

References 121 publications

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“…miRNAs play a critical role in the post-transcriptional regulation of a wide range of physiological processes, including cartilage homeostasis, and the pathological processes in disorders such as OA. 103 , 104 In the past few years, there has been growing emphasis on determining the biological function of miRNAs in regenerative medicine. 105 , 106 Given the eminent role of miRNAs in cartilage regeneration, six studies included here used transfection to upregulate specific miRNAs, ie miR-9-5p, miR-26a-5p, miR-92a-3p, miR-136-5p, miR-140-5p, and miR-155-5p, in exosomes.…”

Section: Resultsmentioning

confidence: 99%

Potential of Exosomes as Cell-Free Therapy in Articular Cartilage Regeneration: A Review

Ng¹,

Chai²,

Foo³

et al. 2021

IJN

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Treatment of cartilage defects such as osteoarthritis (OA) and osteochondral defect (OCD) remains a huge clinical challenge in orthopedics. OA is one of the most common chronic health conditions and is mainly characterized by the degeneration of articular cartilage, shown in the limited capacity for intrinsic repair. OCD refers to the focal defects affecting cartilage and the underlying bone. The current OA and OCD management modalities focus on symptom control and on improving joint functionality and the patient’s quality of life. Cell-based therapy has been evaluated for managing OA and OCD, and its chondroprotective efficacy is recognized mainly through paracrine action. Hence, there is growing interest in exploiting extracellular vesicles to induce cartilage regeneration. In this review, we explore the in vivo evidence of exosomes on cartilage regeneration. A total of 29 in vivo studies from the PubMed and Scopus databases were identified and analyzed. The studies reported promising results in terms of in vivo exosome delivery and uptake; improved cartilage morphological, histological, and biochemical outcomes; enhanced subchondral bone regeneration; and improved pain behavior following exosome treatment. In addition, exosome therapy is safe, as the included studies documented no significant complications. Modifying exosomal cargos further increased the cartilage and subchondral bone regeneration capacity of exosomes. We conclude that exosome administration is a potent cell-free therapy for alleviating OA and OCD. However, additional studies are needed to confirm the therapeutic potential of exosomes and to identify the standard protocol for exosome-based therapy in OA and OCD management.

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Section: Resultsmentioning

confidence: 99%

Potential of Exosomes as Cell-Free Therapy in Articular Cartilage Regeneration: A Review

Ng¹,

Chai²,

Foo³

et al. 2021

IJN

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“…MiR-708-5p could stimulate the apoptosis of fibroblast-like synoviocytes and improve RA through the Wnt3a/β-catenin pathway. 180…”

Section: Circrnas In Ramentioning

confidence: 99%

The role of exosomal non‐codingRNAsin aging‐related diseases

et al. 2021

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“…Several lines of evidence have demonstrated that miR-9 is associated with OA development in human patients [ 75 ], and in a rat OA model, intraarticular injection of miR-9-5p reduces OA pathology by downregulating SDC1 [ 76 ] and suppresses the key matrix metalloproteinase MMP13 77 . Many other miRNAs have been linked, either in vitro or in vivo with OA development (recent miRNA-specific review articles [ 78 , 79 ]).…”

Section: Noncoding Rna Analyses In Oamentioning

confidence: 99%