Exosomes from dental pulp cells attenuate bone loss in mouse experimental periodontitis

Shimizu, Yuta; Takeda-Kawaguchi, Tomoko; Kuroda, Izumi; Hotta, Yasuaki; Kawasaki, Hideya; Hariyama, Takahiko; Shibata, Toshiyuki; Akao, Yukihiro; Kunisada, Takahiro; Tatsumi, Junichi; Tezuka, Kenichi

doi:10.1111/jre.12949

Cited by 28 publications

(20 citation statements)

References 45 publications

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“…Dental pulp stem cell-Exo (DPSC-Exos) can facilitate the conversion of macrophages from a pro-inflammatory phenotype (M1)to an anti-inflammatory phenotype (M2) and promote the healing of alveolar bone in mice with periodontitis, the mechanism of which could be associated with miR-1246 in DPSC-Exos [ 47 ]. Exos purified from human leukocyte antigen haplotype homo dental pulp cell lines (HHH-DPCs) stimulated the migration of human DPCs and mouse osteoblastic and significantly suppressed osteoclast formation in vitro [ 48 ]. Exos secreted from healthy periodontal ligament stem cells (PDLSCs) promote osteogenic differentiation of PDLSCs derived from periodontitis tissue.…”

Section: Exos Based Periodontitis Diagnostic and Treatment Strategymentioning

confidence: 99%

Advances of exosomes in periodontitis treatment

et al. 2022

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Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of tooth-supporting tissue; however, overactivation of the host immune response is the main reason for alveolar bone loss. Periodontal tissue cells, immune cells, and even further activated osteoclasts and neutrophils play pro-inflammatory or anti-inflammatory roles. Traditional therapies for periodontitis are effective in reducing the microbial quantities and improving the clinical symptoms of periodontitis. However, these methods are non-selective, and it is still challenging to achieve an ideal treatment effect in clinics using the currently available treatments and approaches. Exosomes have shown promising potential in various preclinical and clinical studies, including in the diagnosis and treatment of periodontitis. Exos can be secreted by almost all types of cells, containing specific substances of cells: RNA, free fatty acids, proteins, surface receptors and cytokines. Exos act as local and systemic intercellular communication medium, play significant roles in various biological functions, and regulate physiological and pathological processes in numerous diseases. Exos-based periodontitis diagnosis and treatment strategies have been reported to obtain the potential to overcome the drawbacks of traditional therapies. This review focuses on the accumulating evidence from the last 5 years, indicating the therapeutic potential of the Exos in preclinical and clinical studies of periodontitis. Recent advances on Exos-based periodontitis diagnosis and treatment strategies, existing challenges, and prospect are summarized as guidance to improve the effectiveness of Exos on periodontitis in clinics.

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Section: Exos Based Periodontitis Diagnostic and Treatment Strategymentioning

confidence: 99%

Advances of exosomes in periodontitis treatment

et al. 2022

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“…They also have been explored as a MSC alternative in dental root filling in fibrine-based substrates . A previous study of periodontitis showed that DPSC exosomes suppressed alveolar bone resorption by attenuating bone loss in vivo . Swanson et al engineered a biodegradable polymer delivery platform for sustained release of exosomes in craniofacial bone regeneration.…”

Section: Neural Crest Stem Cells: Oral Cavitymentioning

confidence: 99%

Exosomes as Neurological Nanosized Machines

et al. 2022

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In the past few decades, nanomedicine research has advanced dramatically. In spite of this, traditional nanomedicine faces major obstacles, such as blood–brain barriers, low concentrations at target sites, and rapid removal from the body. Exosomes as natural extracellular vesicles contain special bioactive molecules for cell-to-cell communications and nervous tissue function, which could overcome the challenges of nanoparticles. Most recently, microRNAs, long noncoding RNA, and circulating RNA of exosomes have been appealing because of their critical effect on the molecular pathway of target cells. In this review, we have summarized the important role of exosomes of noncoding RNAs in the occurrence of brain diseases.

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“…Some cross-sectional studies have addressed the fact that patients with a fewer number of teeth may be associated with increased risks of stroke or other systemic diseases [ 109 , 110 , 111 ]. On the other hand, if tooth loss is caused during the early years of life or is due to other factors such as caries or trauma, the patients might not have been affected by periodontal disease for the rest of their life [ 112 , 113 ]. In such conditions, negative health effects of poor nutrition and unhealthy eating patterns may contribute indirectly to an increased incidence of stroke [ 114 , 115 ].…”

Section: Relation Between Tooth Conditions and Strokementioning

confidence: 99%

The Link between Stroke Risk and Orodental Status—A Comprehensive Review

Shahi

Farhoudi

Dizaj

et al. 2022

JCM

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One of the primary causes of disability and mortality in the adult population worldwide is stroke. A person’s general health is significantly impacted by their oral and dental health. People who have poor oral health are more susceptible to conditions such as stroke. Stroke risk has long been linked to oral and dental conditions. The risk of stroke and its cost impact on the healthcare systems appear to be significantly reduced as a result of the decline in the incidence and prevalence of oral and dental illnesses. Hypothetically, better management of oral hygiene and dental health lead to reduced stroke risk. To the authors’ best knowledge, for the first time, the potential link between dental health and stroke were cross-examined. The most typical stroke symptoms, oral and dental illnesses linked to stroke, and the role of oral healthcare professionals in stroke prevention are revealed. The potential mediating processes and subsequent long-term cognitive and functional neurological outcomes are based on the available literature. It must be noted that periodontal diseases and tooth loss are two common oral health measures. Lack of knowledge on the effects of poor oral health on systemic health together with limited access to primary medical or dental care are considered to be partially responsible for the elevated risk of stroke. Concrete evidence confirming the associations between oral inflammatory conditions and stroke in large cohort prospective studies, stratifying association between oral disease severity and stroke risk and disease effects on stroke survival will be desirable. In terms of clinical pathology, a predictive model of stroke as a function of oral health status, and biomarkers of systemic inflammation could be useful for both cardiologists and dentists.

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Exosomes from dental pulp cells attenuate bone loss in mouse experimental periodontitis

Cited by 28 publications

References 45 publications

Advances of exosomes in periodontitis treatment

Advances of exosomes in periodontitis treatment

Exosomes as Neurological Nanosized Machines

The Link between Stroke Risk and Orodental Status—A Comprehensive Review

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