Expand+In Vivoiv.iiarjournals.orgIn Vivo September-October 2017 vol. 31 no. 5 877-884  Antrodia Cinnamomea Reduces Carbon Tetrachloride-induced Hepatotoxicity In Male Wister Rats

Shih, Yu‐Lueng; Wu, Ming; Lee, Ching Hsiao; Yeh, Ming‐Yang; Chou, Jason; Liu, Jia You; Lu, Hsu Feng; Huang, Yi Ping; Liao, Nien Chieh; Chung, Jing Gung

doi:10.21873/invivo.11142

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…It has been reported that lipid peroxidation, reducing activity of antioxidant enzymes, and generation of free radicals are the primary reasons of CCl 4 -induced hepatic injury [ 38 ]. Previous studies have already shown that one of the main causes of CCl 4 -induced hepatotoxicity is the generation of lipid peroxides by free radical derivatives of CCl 4 [ 39 ]. Thus, the antioxidant activity or the inhibition of the generation of free radicals could be one of the mechanisms in the protection against CCl 4 -induced hepatotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Toxicological Evaluation and Hepatoprotective Efficacy of Rosmarinic Acid-Rich Extract from Ocimum basilicum L.

Touiss

Ouahhoud

Harnafi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Exposure to carbon tetrachloride (CCl4) induces acute and chronic liver injuries as well as oxidative stress in rats. The present study was designed to evaluate the in vivo toxicity of rosmarinic acid-rich extract from Ocimum basilicum (RAE). The acute and subchronic oral toxicity of RAE was evaluated in Albinos mice. Hepatotoxicity was induced by the administration of CCl4-induced hepatic injury in rats. The hepatoprotective effect of RAE on aspartate aminotransferase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, bilirubin, total protein, albumin, triglycerides, total cholesterol, low-density lipoprotein, high-density lipoprotein, plasmatic glucose, urea, creatinine, and malondialdehyde was determined in CCl4-intoxicated rat. The extract did not produce treatment-related signs of toxicity or mortality in any of the animals tested during acute as well as subchronic toxicity studies. The administration of CCl4 resulted in marked increase in plasma hepatic enzymes p < 0.001 and significant decrease of total protein p < 0.001 and albumin p < 0.001 when compared to normal. The RAE at 200 mg/kg body weight lowered significantly p < 0.001 plasma enzyme activities of liver, which is designation of hepatoprotective action of extract. The phenolic extract exerts a significant increase in total protein p < 0.001 , and albumin p < 0.001 , accompanied with a marked reduction in the levels of malondialdehyde p < 0.001 , as compared to CCl4-treated group. Our study suggests that RAE may be used as a hepatoprotective agent against toxic effects caused by CCl4 and other chemical agents in the liver.

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Section: Discussionmentioning

confidence: 99%

Toxicological Evaluation and Hepatoprotective Efficacy of Rosmarinic Acid-Rich Extract from Ocimum basilicum L.

Touiss

Ouahhoud

Harnafi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Non-cross-linked collagen type I microfibers for improved hemostasis and wound healing

et al. 2022

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Literature Review of Traditional Chinese Medicine Herbs–Induced Liver Injury From an Oncological Perspective With RUCAM

Chow

Choi

et al. 2019

Integr Cancer Ther

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Traditional Chinese medicine (TCM) herbs are commonly regarded to be safe with minimal toxicities in Chinese communities. Cancer patients who are receiving Western oncology therapy often concurrently take TCM herbs for anticancer and symptom relief purposes. We performed a literature review for current evidence on TCM herb–induced liver injury from an oncological perspective. A literature search on PubMed was performed to identify publications regarding TCM herbs and concoctions with hepatoprotective or hepatotoxic properties. Lists of commonly used herbs and their causality levels were compiled. In view of the wide range of evidence available, cases assessed by the well-established RUCAM (Roussel Uclaf Causality Assessment Method) algorithm were categorized as the highest level of evidence. More than one case of TCM herb–induced liver injury was confirmed by RUCAM in the following herbs and concoctions: Lu Cha ( Camellia sinensis), Bai Xian Pi ( Dictamnus dasycarpus), Tu San Qi ( Gynura segetum), Jin Bu Huan ( Lycopodium serratum), He Shou Wu ( Polygoni multiflora), Ge Gen ( Pueraria lobata), Dan Lu Tong Du tablet, Shou Wu Pian, Xiao Chai Hu Tang, Xiao Yin pill, and Yang Xue Sheng Fa capsule. Finally, TCM with anticancer or symptom relief uses were discussed in detail with regard to their hepatotoxic or hepatoprotective properties.

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Expand+In Vivoiv.iiarjournals.orgIn Vivo September-October 2017 vol. 31 no. 5 877-884 Antrodia Cinnamomea Reduces Carbon Tetrachloride-induced Hepatotoxicity In Male Wister Rats

Abstract: Abstract. Background/Aim: Antrodia cinnamomea is foundwith polysaccharides, lipids, vitamins, fibers and ash (minerals)

Cited by 3 publications

References 35 publications

Toxicological Evaluation and Hepatoprotective Efficacy of Rosmarinic Acid-Rich Extract from Ocimum basilicum L.

Toxicological Evaluation and Hepatoprotective Efficacy of Rosmarinic Acid-Rich Extract from Ocimum basilicum L.

Non-cross-linked collagen type I microfibers for improved hemostasis and wound healing

Literature Review of Traditional Chinese Medicine Herbs–Induced Liver Injury From an Oncological Perspective With RUCAM

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