In this thesis, a novel vacuum infiltration technique was developed to fabricate porous alumina ceramics. The preparation and characterization of porous alumina ceramics with a bioactive glass coating was reported. The obtained porous materials were expected to find implantation applications including bone replacement and bone regeneration, because they would have the ability to induce bone ingrowth and bone bonding, and maintain sufficient mechanical strengths to support the physiological loads. The project was focused on the relationships between the processing, microstructure and properties of the porous alumina ceramics. Highly porous alumina/zirconia ceramics were successfully prepared using porous expanded polystyrene (EPS) bead templates as the pore former. A vacuum infiltration process was developed to prepare the porous bodies, in which ceramic slurries were allowed to penetrate into the pore spaces of the porous EPS template. After drying, the ceramic particle-pore former compacts were fired in air to burn out the pore formers and densify the ceramic struts. Finally, the porous structure, which was negatively duplicated from the pore structure of the porous EPS bead, was obtained. The prepared porous alumina ceramics were featured with controllable pore sizes ranging from 1.21mm to 2.63mm, high total porosities about 60.84%-65.93%, high open porosities above 48.32%, and excellent pore interconnectivity. The mechanical properties of all the porous ceramics decreased with the increase of the porosity. With the pore sizes of porous alumina ceramics increasing from 1.21mm to 2.63mm, the compressive strength decreased ATTENTION: The Singapore Copyright Act applies to the use of this document. Nanyang Technological University Library Chapter 1 General Introduction Chapter 1 General Introduction 1.1 Background Bone is the substantial unit of human skeletal system which functions as load bearing, protection of most vital internal organs and storage of minerals. Pathologies of bone have substantial impacts on the health and quality of life of the population. The revolution of replacement of bone tissues by transplants and implants has led to a remarkable increase in the quality of life for millions of patients. The surgical methods involves: autografting (using patient's own bone), allografting (using donor's bone), xenografting (using animal's bone), synthetic graft (biomaterials) and tissue engineering (biomaterials and cell). The former three methods all use the natural materials, but are limited by the scarce supply of the grafts. Besides, great concerns exist in the immune response and infection. As a result, a synthetic graft method was developed to use biomaterials with desired shapes and forms to serve as the implantable grafts. Due to the plenty of supply and excellent biocompatibility of biomaterials, the synthetic grafts are still widely used in clinical surgery up to now. From 1970s, with the development of biology, a novel method, tissue engineering, has become emerging and potential method for trea...