Although recent years have seen large decreases in the overall global rate of suicide fatalities, this trend is not reflected everywhere. Suicide and suicidal behaviour continue to present key challenges for public policy and health services, with increasing suicide deaths in some countries, such as the USA. The development of suicide risk is complex, involving contributions from biological (including genetics), psychological (such as certain personality traits), clinical (comorbid psychiatric illness), social and environmental factors. The involvement of multiple risk factors in conveying risk of suicide means that determining an individual's risk of suicide is challenging. Improving risk assessment, for example using computer testing and genetic screening, is an area of ongoing research. Prevention is key to reduce the number of suicide deaths, and current efforts include universal, selective and indicated interventions, although these interventions are often delivered in combination. These interventions, combined with psychological (such as cognitive behavioural therapy, caring contacts and safety planning) and pharmacological treatments (for example, clozapine and ketamine) and coordinated social and public health initiatives, should continue to improve the management of suicidal patients and decrease suicide-associated morbidity. [H1] Epidemiology Based on self-report survey data, the WHO has estimated that for every death by suicide ~20 people make suicide attempts 1. This ratio varies from country to country depending on the lethality of commonly used suicide methods. In all countries, the incidence of suicide attempts is highest in individuals 15-24 years of age. By comparison, the lowest rates of suicide is observed amongst young people <15 years of age, with the highest generally observed in people >75 years of age 1. However, the age-groups with the highest incidence at other ages vary from region to region; for example, in a 25