Expanding the Iroquois genes repertoire: a non-transcriptional function in cell cycle progression

The homeobox factor Irx3 maintains adipogenic identity

“…This observation caught our attention, as we previously found cell-cycle genes to be significantly downregulated following siRNA-mediated knock-down of either IRX3 or IRX5 in human primary preadipocytes [287,289]. Moreover, other studies have also found IRX3 or IRX5 to be involved in cell-cycle regulation [235,236,290] and proliferation/cancer development [237]. We therefore hypothesized that Irx3 might control adipogenesis via MCE.…”

“…The IRX class consists of six family members (IRX1-6) that share a unique and highly conserved 9 aa IRO box C-terminal of the HD [199,201,202]. Until recently, the function of the IRO domain was unknown, but recent evidence from Drosophila suggests this domain is involved in protein-protein interactions [203].…”

Circular RNA circLAMA3 inhibits the proliferation of bladder cancer by directly binding an mRNA

“…Studies have demonstrated that CDK4/CDK6 interact with cyclin D to promote the phosphorylation of the pRb protein, thereby activating DNA replication during the S phase. 18 CDK2 promotes the G1/S transition by combining with cyclin E during the G1 phase, 19 and CDK2 participates in S phase replication initiation by combining with cyclin A. 20 In addition, cyclin B has been reported to be active throughout the mitotic stage.…”

Iroquois Family Genes in Gastric Carcinogenesis: A Comprehensive Review

“…Moreover, the Ras/MAPK pathway modulates the transcriptional activity of araucan / caupolican [ 47 ]. Iro genes can control cell cycle progression in Drosophila because Iro proteins can downregulate the activity of the Cyclin E/Cdk2 complex [ 48 ], which is often lost in tumor cells [ 49 ]. In the prospective notum in Drosophila, the early activation of Iro-C seems to be promoted through EGFR.…”