Expanding the pathologic spectrum of light chain deposition disease: a rare variant with clinical follow-up of 7 years

Light chain only variant of proliferative glomerulonephritis with monoclonal immunoglobulin deposits is associated with a high detection rate of the pathogenic plasma cell clone

“…The endocapillary proliferative glomerulonephritis pattern in PGNMID-LC may be an acute stage of the disease, although follow-up biopsies were not performed in our 3 patients with this pattern to confirm this theory. Although we did not observe extraglomerular LC deposits in our patients, Chang et al 22 reported a patient with PGNMID-LC in whom there was focal tubular basement membrane and interstitial deposition of k in addition to the massive glomerular deposition.…”

“…18,19 However, exceptional cases of PGNMID characterized by a deposition of nonorganized MIg LCs only (PGNMID-LC) have been reported. [20][21][22][23] Herein, we describe the first clinicopathologic and proteomic series of PGNMID-LC. The aim of this multicenter study was to define clinical, immunopathologic features and outcomes of PGNMID-LC, and to shed some light into its pathogenesis.…”

Natural history and outcome of light chain deposition disease

“…9,12,16,17 Liver LCDD was confirmed histologically in both cases in which it was suspected biochemically, and lung LCDD was confirmed by surgical lung biopsy in a patient with panacinar emphysema. 18 …”

Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Light Chain Deposits: A Rare Entity Mimicking Immune-Complex Glomerulonephritis

“…a high prevalence of underlying hematological malignancies and a severe outcome (8). Chang et al (9) reported an unusual histological variant of LCDD (κ-type), in which electron microscopy revealed massive immune-complex deposition. In that case, the light microscopic findings resembled the wire-loop deposits of lupus nephritis.…”