2021
DOI: 10.1039/d1tb02154k
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Expanding the spectrum of polydopamine antioxidant activity by nitroxide conjugation

Abstract: Polydopamine (PDA) materials are important due to their unique physicochemical properties and their potential as chemopreventive agents for diseases connected with oxidative stress. Although PDA has been suggested to have...

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Cited by 18 publications
(16 citation statements)
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References 49 publications
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“…Melanin-inspired polydopamine nanoparticles (PDA NPs) have been widely investigated in many fields due to their excellent properties, such as imaging, [1,2] UV protection, [3,4] energy applications, [5,6] biomedical applications, [7][8][9] photothermal conversion, [10][11][12][13][14][15] free radical scavenging [16][17][18] and structural DOI: 10.1002/marc.202100916 coloration. [19,20] In these studies, particle size usually has a great influence on the properties of such materials, so the rigorous control and fine tuning of particle size are quite important.…”
Section: Introductionmentioning
confidence: 99%
“…Melanin-inspired polydopamine nanoparticles (PDA NPs) have been widely investigated in many fields due to their excellent properties, such as imaging, [1,2] UV protection, [3,4] energy applications, [5,6] biomedical applications, [7][8][9] photothermal conversion, [10][11][12][13][14][15] free radical scavenging [16][17][18] and structural DOI: 10.1002/marc.202100916 coloration. [19,20] In these studies, particle size usually has a great influence on the properties of such materials, so the rigorous control and fine tuning of particle size are quite important.…”
Section: Introductionmentioning
confidence: 99%
“…In contrast, the cells in the Hybrid‐2 group continued to metabolize, even when cultured for 8 weeks. The antioxidant role of polydopamine [ 44 ] may partly explain the differences observed in the Hybrid‐1 and Hybrid‐2 groups; allowing the cells to improve the cell–material interactions is likely to have improved the problems of apoptosis and necrosis by preventing oxidative stress.…”
Section: Resultsmentioning
confidence: 99%
“…We expect such mutual activation of phenols and nitroxyls to be conserved among many ArOH/TEMPO • pairs reacting with ROO • in biological systems. Cooperation of phenols with nitroxyls might be of practical importance for the design and synthesis of hybrid compounds with nitroxyl and phenol functionalities, resulting in materials and biomaterials with improved antiradical activity, as recently proposed for polydopamine nanoparticles decorated with nitroxyls …”
Section: Discussionmentioning
confidence: 99%