Expanding the ZIFs Repertoire for Biological Applications with the Targeted Synthesis of ZIF-20 Nanoparticles

Deneff, Jacob I.; Butler, Kimberly S.; Kotula, Paul Gabriel; Rue, Braden E; Gallis, Dorina F. Sava

doi:10.1021/acsami.1c05657

Cited by 20 publications

(25 citation statements)

References 50 publications

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“…While the toxicity profiles vary, the observed IC 50 values for all but the ZIF‐76 MbIM in macrophage cells fall within previously observed IC 50 values for MOFs for biomedical applications including ZIF‐8 and ZIF‐20 in epithelial and macrophage cells. [ 26,47,49,50 ] Previous studies have found the IC 50 values of ZIF‐8 to be ≈25–30 µg ml −1 in macrophage cells and ≈100 µg ml −1 in epithelial cells. [ 47,50 ] ZIF‐76 shows a very similar toxicity profile which supports the observation that Zn ions can cause cell toxicity due to stimulating mitochondrial reactive oxygen species (ROS) production at high doses.…”

Section: Resultsmentioning

confidence: 99%

Harnessing Particle Size‐Control and DNA‐Oligo Functionalization in ZIF‐76 for Biological Applications

Deneff

Butler

Reyes

et al. 2022

Adv Materials Inter

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effects that limit therapeutic efficacy. To counter these problems, a wide range of complex nanocarriers have been explored as vectors for drug delivery, protecting delicate cargos from rapid degradation and enabling cargo delivery directly into cells, in addition to supporting imaging and sensing applications. [1][2][3] Among the wide range of options, zeolitic imidazolate frameworks (ZIFs) in particular have emerged as a promising, tunable materials platform in this field. [4][5][6][7] ZIFs represent a subset of metalorganic frameworks (MOFs) materials, that possess zeolite-like topologies and are built from imidazole-based organic linkers. Importantly, imidazole-based linkers are a broad family with varied chemistry, allowing tunability, facilitating larger porosity than in traditional zeolitic materials, and increased chemical tunability due to the variety of imidazole derivatives available. A rich family of related ZIF frameworks has been developed over the years, highlighting increased overall structural and chemical diversity. [8][9][10][11] While much of their chemical diversity in ZIFs has focused on other applications, [12] ZIFs are also well suited for biological applications owing to the high biocompatibility of both starting reagents, zinc metal, and imidazolate organic linkers. [13][14][15] Due to their biocompatibility, a large body of work exists concerning both encapsulation of cargo and drug delivery using ZIF nanoparticles, but the field is limited by the almost universal use of the prototypical ZIF-8, a material derived from a 2-methyl imidazole linker resulting in the sod topology. [4,5,7] As highlighted above, between different imidazole chemistries and different topologies, there are many known ZIF structures that have never been applied to the biological realm as well as novel ZIF structures that remain unexplored. Moreover, recent developments demonstrated rational ways of targeting novel, highly intricate zeolitic structures with extra-large cages, based on the size and shape of the imidazole-based linkers use in the synthesis. [9] Given the diversity of ZIF structures available, a significant opportunity exists to expand the functional space of ZIFs available for biological use. The implementation of distinct topologies would allow for the targeted use of hierarchical pore sizes, along with the introduction of more than one chemical functional group via the imidazole linker. These factors alter the dynamics of cargo encapsulation and release, both in Advanced therapeutics require novel nanocarriers to ensure their functionality is preserved during transit. Zeolitic imidazolate frameworks (ZIFs) have emerged as promising materials in this field owing to their combined biocompatibility, high porosity, and tunable chemistry. While a diverse family of ZIFs has been reported, few have been explored beyond the prototypical ZIF-8. Herein, the size-controlled synthesis of three distinct ZIF-76 analogs is demonstrated, overcoming the unique synthetic challenges intrinsic to the lta topology and ...

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Section: Resultsmentioning

confidence: 99%

Harnessing Particle Size‐Control and DNA‐Oligo Functionalization in ZIF‐76 for Biological Applications

Deneff

Butler

Reyes

et al. 2022

Adv Materials Inter

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“…They possess unique structural features, a substantial surface area, a tunable pore diameter, unsaturated metal coordination nodes, and abundant organic ligands [1]. Over the past twenty years, MOFs of various MIL [2,3], UIO [4,5], and ZIF series [6,7] have been prepared, and more than 20,000 have been reported so far. MOFs have been found to possess a good amount of redox sites and can be utilized in a variety of domains such as catalysis, electrochemical sensing, adsorption, removal, and drug delivery [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Beyond Pristine Metal–Organic Frameworks: Preparation of Hollow MOFs and Their Composites for Catalysis, Sensing, and Adsorption Removal Applications

et al. 2022

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Metal–organic frameworks (MOFs) have been broadly applied to numerous domains with a substantial surface area, tunable pore size, and multiple unsaturated metal sites. Recently, hollow MOFs have greatly attracted the scientific community due to their internal cavities and gradient pore structures. Hollow MOFs have a higher tunability, faster mass-transfer rates, and more accessible active sites when compared to traditional, solid MOFs. Hollow MOFs are also considered to be candidates for some functional material carriers. For example, composite materials such as hollow MOFs and metal nanoparticles, metal oxides, and enzymes have been prepared. These composite materials integrate the characteristics of hollow MOFs with functional materials and are broadly used in many aspects. This review describes the preparation strategies of hollow MOFs and their composites as well as their applications in organic catalysis, electrochemical sensing, and adsorption separation. Finally, we hope that this review provides meaningful knowledge about hollow-MOF composites and their derivatives and offers many valuable references to develop hollow-MOF-based applied materials.

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“…Therefore, ammonia, displaying the highest polarizability of the three gas molecules, can selectively adsorb within the ZIF-21 pores facilitating its capture/separation from N 2 /H 2 . However, since the seminal work by Yaghi’s group, there have been limited reports on ZIF-21 but several studies on its analogue material ZIF-20 (zinc metal sites with a purine linker). − …”

Section: Introductionmentioning

confidence: 99%

ZIF-21 Crystals: Its Morphology Control and Potential as an Adsorbent for Ammonia Capture

et al. 2022

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The selective adsorption of NH3 over N2 and H2 is of interest for ammonia separation and synthesis. Zeolitic imidazolate frameworks (ZIFs) having tunable pores, high surface area, and chemical affinity for ammonia are suitable candidates for this particular application. Herein, we explore the influence of synthesis parameters on the morphology of ZIF-21 formed by hydrothermal synthesis. Among the many variables examined, it was found that the addition of weak bases such us sodium formate (SF) and weak acids such as ethylenediaminetetraacetic acid (EDTA) acts as crystal morphology modifiers to improve the crystallinity and morphology of ZIF-21 crystals. The addition of EDTA led to the formation of crystals with significant improvements in ammonia adsorption performance without modifying the characteristic LTA topology of ZIF-21. The resultant ZIF-21 crystals led to octahedral uniform shapes displaying remarkably high NH3/N2 and NH3/H2 ideal selectivities. Specifically, ideal selectivities of NH3/N2 = 400 and NH3/H2 = 390 were observed, which correspond to an ∼7- and 8-fold improvement as compared to pristine ZIF-21 (without the addition of EDTA), respectively. Besides the improved and regular ZI-21 morphology, two main factors led to the high observed NH3/N2 and NH3/H2 ideal selectivities of the EDTA-assisted ZIF-21 crystals: ammonia pore size confinement and enhanced polar–polar interactions between NH3 and polar ZIF-21 walls. Extended exposure to ammonia partially degraded the ZIF-21 crystal structure by reaction with the purine linkers.

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Expanding the ZIFs Repertoire for Biological Applications with the Targeted Synthesis of ZIF-20 Nanoparticles

Cited by 20 publications

References 50 publications

Harnessing Particle Size‐Control and DNA‐Oligo Functionalization in ZIF‐76 for Biological Applications

Harnessing Particle Size‐Control and DNA‐Oligo Functionalization in ZIF‐76 for Biological Applications

Beyond Pristine Metal–Organic Frameworks: Preparation of Hollow MOFs and Their Composites for Catalysis, Sensing, and Adsorption Removal Applications

ZIF-21 Crystals: Its Morphology Control and Potential as an Adsorbent for Ammonia Capture

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