Expected impact of immunomodulatory agents during pregnancy: A newborn's perspective

Luo, Yiyi; Acevedo, Daniel Camilo Aguirre; Baños, Núria; Pluma, Andrea; Castellanos‐Moreira, Raúl; Moreno, Estefanía; Rodriguez-García, S. C.; Deyà‐Martínez, Àngela; García‐García, A.; Quesada-Masachs, Estefanía; Torres, Mireia; Casellas, M.; Grados, Dolors; Martí‐Castellote, Celia; Antón, Jordi; Vlagea, Alexandru; Juan, Manel; Esteve‐Solé, Ana; Alsina, Laia

doi:10.1111/pai.13911

Cited by 10 publications

(2 citation statements)

References 77 publications

(162 reference statements)

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“…Concerning the Eo/Bas cluster, we observed a high and exclusive expression of anti-inflammatory cytokines Il4 and Il13 . In line with our observations, basophil cells in newborns were shown to skew the differentiation of T cells towards Th2, which in newborns have an anti-inflammatory profile to protect intestinal microbiota and prevent tissue damage (Dhakal et al, 2015; Luo et al, 2023). Highlighting the predicted interdependency between compartments, both hematopoietic clusters also express key factors mediating bone healing ( Ccl5 (Ortinau et al, 2019) in ILC-TSP2) and osteogenesis-adipogenesis balance ( Osm (Li et al, 2022a) in Eo/Bas).…”

Section: Discussionsupporting

confidence: 89%

The cellular landscape of the endochondral bone during the transition to extrauterine life

Rueda,

Salvador-Martínez,

Sospedra-Arrufat

et al. 2023

Preprint

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The cellular complexity of the endochondral bone underlies its essential and pleiotropic roles during organismal life. While the adult bone has received significant attention, we still lack a deep understanding of the perinatal bone cellulome. Here, we have profiled the full composition of the murine endochondral bone at the single-cell level during the transition from fetal to newborn life and in comparison to the adult organ, with particular emphasis on the mesenchymal compartment. The perinatal bone contains different fibroblastic clusters with blastema-like characteristics in organizing and supporting skeletogenesis, angiogenesis, and hematopoiesis. Our data also points out to a dynamic inter- and intra-compartment interactions as well as a bone marrow milieu prone to anti-inflammation, which we hypothesize is necessary to ensure the proper program of lymphopoiesis and the establishment of central and peripheral tolerance in early life. Our study provides a integrative roadmap for the future design of genetic and cellular functional assays to validate cellular interactions and lineage relationships within the perinatal bone.

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Section: Discussionsupporting

confidence: 89%

The cellular landscape of the endochondral bone during the transition to extrauterine life

Rueda,

Salvador-Martínez,

Sospedra-Arrufat

et al. 2023

Preprint

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show abstract

“…The use of immunomodulators during pregnancy has gained global interest. Current evidence mainly reports outcomes related to the newborn and the potential effect on the ontogeny of the immune system [56]. Previous studies have reported the effects of cytokines [21,57] as immunomodulators capable of acting on blood viscosity.…”

Section: Discussionmentioning

confidence: 99%

Serotonin and Interleukin 10 Can Influence the Blood and Urine Viscosity in Gestational Diabetes Mellitus and Pregnancy-Specific Urinary Incontinence

França,

Honorio-França,

Silva

et al. 2023

IJMS

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Serotonin and interleukin 10 (IL-10) may play a role in gestational diabetes mellitus. Hyperglycemic environment, the detrusor musculature of the bladder and pelvic floor muscles may become damaged, leading to urination problems and urine viscosity in pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. Urine and blood samples were collected from pregnant women between 24 and 28 weeks of gestation. The serotonin concentration and cytokine IL-10 levels were evaluated in plasma and urine. In the total blood and urine, the viscosity was evaluated in the presence and absence of exogenous serotonin and IL-10. The plasma serotonin levels decreased, while the urine serotonin levels increased in the normoglycemic incontinent (NG-I), hyperglycemic continent (GDM-C), and hyperglycemic incontinent (GDM-I) groups. The IL-10 in the plasma decreased in the GDM-I group and was higher in the urine in the NG-I and GDM-I groups. The blood viscosity was higher, independently of urinary incontinence, in the GDM groups. The serotonin increased the blood viscosity from women with GDM-C and urine in the NG-I, GDM-C, and GDM-I groups. Blood and urine in the presence of IL-10 showed a similar viscosity in all groups studied. Also, no difference was observed in the viscosity in either the blood or urine when in the presence of serotonin and IL-10. These findings suggest that serotonin and IL-10 have the potential to reduce blood viscosity in pregnant women with gestational diabetes and specific urinary incontinence, maintaining values similar to those in normoglycemic women’s blood.

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Exposure to medication for neurological disease in pregnancy – time to consider the long-term implications?

Liu,

Pace,

Bromley

et al. 2023

eClinicalMedicine

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Expected impact of immunomodulatory agents during pregnancy: A newborn's perspective

Cited by 10 publications

References 77 publications

The cellular landscape of the endochondral bone during the transition to extrauterine life

The cellular landscape of the endochondral bone during the transition to extrauterine life

Serotonin and Interleukin 10 Can Influence the Blood and Urine Viscosity in Gestational Diabetes Mellitus and Pregnancy-Specific Urinary Incontinence

Exposure to medication for neurological disease in pregnancy – time to consider the long-term implications?

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