Experience-dependent alteration of zinc-containing circuits in somatosensory cortex of the mouse

Quaye, V.L; Shamalla-Hannah, Lorraine; Land, Peter W.

doi:10.1016/s0165-3806(99)00042-5

Cited by 19 publications

(9 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With this background, we then determined the influence of vibrissa-tactile experience on development of zincergic circuits by depriving rats of whisker input during restricted periods of postnatal life. We observed abnormally intense staining of synaptic zinc in barrels of rats and mice that had been chronically deprived of whisker input from P0 through P42 in previous studies (Land and Akhtar, 1999;Quaye et al, 1999). We had two goals in the present investigation.…”

Section: Materials and Methods Animalsmentioning

confidence: 86%

“…Cortical barrels of adult rats and mice contain a very low density of zinc-containing terminals (Czupryn and Skangiel-Kramska, 1997;Land and Akhtar, 1999;Quaye et al, 1999;see Fig 1). This is consistent with the fact that both thalamocortical and intrinsic barrel neurons-the principal glutamatergic inputs to lamina IV-do not sequester zinc (see above).…”

Section: Zinc Innervation Of Lamina IV Barrelsmentioning

confidence: 99%

“…Zincergic pathways thus constitute a unique subset of excitatory circuits that are likely to have distinctive functional roles. (Land and Akhtar, 1999) and mice (Czupryn and Skangiel-Kramska, 1997;Quaye et al, 1999) and in the visual cortex (V1) of mice (Garret and Slomianka, 1992), cats, and monkeys density of zinc-containing terminals is highest in supragranular laminae and in lamina V, intermediate in lamina VI, and exceedingly low in portions of lamina IV. Regions with the lowest density of synaptic zinc, such as the centers of vibrissa-related barrels in rodent S1 and lamina IVc in monkey V1, exhibit intense cytochrome oxidase (CO) activity Land and Akhtar, 1999).…”

mentioning

confidence: 99%

“…Depriving an infant rodent of normal tactile experience by trimming its vibrissae (whiskers) for the first 4 -6 weeks of life results in markedly increased density of zinc-containing terminals in deprived vs. nondeprived cortical barrels (Land and Akhtar, 1999;Quaye et al, 1999). The same trimming paradigm leads to permanent abnormalities in barrel neuron receptive fields (Simons and Land, 1987) and in pronounced behavioral deficits when the regrown hairs are used in tactile discrimination tasks (Carvell and Simons, 1996).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Experience‐dependent plasticity of zinc‐containing cortical circuits during a critical period of postnatal development

Land

Shamalla-Hannah

2002

J of Comparative Neurology

View full text Add to dashboard Cite

Distinctive subsets of glutamatergic neurons in cerebral cortex sequester the transition metal zinc within the synaptic vesicles of their axon terminals. In the present study we used histochemical localization of synaptic zinc to investigate normal postnatal development and experience-dependent plasticity of zinc-containing circuits in somatosensory barrel cortex of rats. First, we found that zinc-containing cortical circuits are dynamically reorganized between postnatal day (P) 0 and P28. Whereas most cortical laminae exhibited idiosyncratic increases in zinc histochemical staining with advancing age, lamina IV barrels were darkly reactive early in life and then lost much of their complement of synaptic zinc during postnatal weeks 2-4. Second, we established that sensory experience plays a major role in sculpting the zinc-containing innervation of cortical barrels. Trimming a particular facial whisker arrested the normal postnatal decline in synaptic zinc in the corresponding, deprived barrel. This resulted in more intense zinc staining in deprived barrels compared with adjacent, nondeprived barrels. Notably, the influence of experience on development of zinc circuits was most robust during a critical period extending from about P14, when an effect of whisker trimming first could be observed, through P28, after which time chronic deprivation no longer resulted in heightened levels of synaptic zinc in lamina IV. These findings indicate that sensory input can have a marked influence on development of cortical circuits, including those within lamina IV, throughout the first postnatal month.

show abstract

Section: Materials and Methods Animalsmentioning

confidence: 86%

Section: Zinc Innervation Of Lamina IV Barrelsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Experience‐dependent plasticity of zinc‐containing cortical circuits during a critical period of postnatal development

Land

Shamalla-Hannah

2002

J of Comparative Neurology

View full text Add to dashboard Cite

show abstract

“…Statistical analyses were performed by averaging across all cells per hemisphere. Since many mice are barbered from infancy, the brains from separate groups of animals were subject to staining for cytochrome oxidize ( [11]; n = 6…”

Section: Histological Methodsmentioning

confidence: 99%

The Dalila effect: C57BL6 mice barber whiskers by plucking

Sarna

2000

Behavioural Brain Research

116

View full text Add to dashboard Cite

Group-housed laboratory mice are frequently found with their whiskers and facial hair removed. It has been proposed that dominant mice are responsible for barbering the hair of the recipient (the Dalila effect), and early studies suggest that the hair is removed by nibbling. In the present study, pairs of C57BL6 mice, composed of a barber and recipient, were separated to allow hair to regrow. The animals were then placed together in an observation box and their social behavior was videorecorded. The videorecording was subjected to frame-by-frame analysis. Barbering was found to occur during acts of mutual grooming. During grooming, one member of a mouse pair removed the vibrissae of the conspecific and did so by grasping individual whiskers with the incisors and plucking them out. Although plucking appeared 'painful', recipients were passive in accepting barbering, and even pursued conspecifics for further grooming. Other measures indicated that barbers were heavier than recipients and brain weights were not different. Although cortical barrel fields appeared normal to cytochrome oxidization and zinc staining, Golgi analysis of layer three, barrel-field basilar dendrites indicated changes in cell morphology. The results are discussed in relation to the hypothesis that barbering is an expression of social dominance, the origins of the barbering behavior, and the consequences of barbering on brain function.

show abstract

Transient expression of synaptic zinc during development of uncrossed retinogeniculate projections

Land

Shamalla-Hannah

2001

J of Comparative Neurology

View full text Add to dashboard Cite

The transition metal zinc is an essential dietary constituent that is believed to serve an important intercellular signaling role at certain excitatory synapses in the central nervous system. In the present study, we used histochemical techniques to investigate the distribution of synaptic zinc during postnatal development of retinogeniculate projections in rats. From postnatal day (P) 1 until P-21, the pattern of zinc histochemical staining in the dorsal lateral geniculate nucleus (LGNd) precisely matched the distribution of axon terminals from the ipsilateral eye that were labeled by anterograde transport of horseradish peroxidase. Regions of the LGNd that contained only crossed axons were devoid of zinc staining. Abnormalities in the distribution of uncrossed retinogeniculate projections in albino versus pigmented rats were paralleled by identical variations in localization of synaptic zinc. Unilateral enucleation on P-10 was followed within 5 days by loss of zinc staining in the LGNd ipsilateral to the removed eye without affecting staining in the contralateral nucleus. Finally, the ability to detect zinc histochemically in the LGNd ceased at approximately P-24. These findings provide evidence that zinc is sequestered within synaptic boutons of a subpopulation of retinal ganglion cells whose axons terminate on the ipsilateral side of the brain. The duration of zinc staining overlaps with the major period of axonal remodeling in the LGNd, suggesting that synaptically released zinc may play a role in postnatal refinement of retinogeniculate projections.

show abstract

Experience-dependent alteration of zinc-containing circuits in somatosensory cortex of the mouse

Cited by 19 publications

References 22 publications

Experience‐dependent plasticity of zinc‐containing cortical circuits during a critical period of postnatal development

Experience‐dependent plasticity of zinc‐containing cortical circuits during a critical period of postnatal development

The Dalila effect: C57BL6 mice barber whiskers by plucking

Transient expression of synaptic zinc during development of uncrossed retinogeniculate projections

Contact Info

Product

Resources

About