Experience in the use of isotretinoin in patients with rosacea fulminans (clinical case)

Kondrat’eva, Yu. S.; Kokina, O. A.; Eroshenko, N. V.; Titkova, K. V.

doi:10.17116/klinderma201514591-96

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…рапии, хотя его назначение подкреплено федеральными клиническими рекомендациями [13]. Имеются данные о назначении изотретиноина при фульминантной розацеа, хотя существование такой формы в настоящее время дискутируется [18]. Назначение антибиотикотерапии снижает воспалительный компонент, но может оказать только временный результат, сопровождаться побочными эффектами в виде гастроинтестинальных расстройств, фоточувствительности, генитального кандидоза и пр.…”

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Systemic therapy in patients with severe rosacea

Bakhlykova¹,

Филимонкова²,

Matusevich³

2016

Vestnik dermatologii i venerologii

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Rosacea is a polietiologic disease with a complex pathogenesis, resulting in the problem is the selection of therapeutic tactics, especially in severe disease. The result of the study revealed that the isotretinoin treatment for rosacea had a positive result, even in the absence of the effect of previous systemic antibiotic therapy. Aim of the study. To study the effect and tolerability of systemic isotretinoin treatment for severe rosacea that is resistant to antibiotic therapy. Materials and methods. Under the supervision and treatment were 16 patients with severe course of rosacea, 14 of them had pustules and papules and 2 - fimatodes subtype. The severity was estimated by the method a 4-point scale proposed by V.P. Adaskevich, and was in average 18.6 points. All patients had a duration of 3 ± 1.2 years for systemic antibacterial therapy (clarithromycin, Ornidazole) with insufficient effect in the past. All patients (n = 16) was conducted therapy with isotretinoin (using Aknekutan). Daily dose was calculated on body weight, the initial dose was 0.2-0.3 mg/ kg, with subsequent dose reduction. Topically patients received clindamycin phosphate gel 1% treatment (5-7 days), then metronidazole 1% cream (Rosamet) 1-2 times a day. The duration of therapy ranged from 3 to 5 months. Results. After the course of therapy using Aknekutan remission or significant improvement was achieved in 87.5% of cases. The severity of the disease fell to 6.5 points, i.e. 2.8 times. Conclusion. Aknekutan showed a high therapeutic effect in severe rosacea, so it can be recommended to patients with resistance to conventional therapy. As external therapy, and supportive treatment patients are recommended - cream metronidazole 1% (Rosamet) and adequate skin care, photoprotective creams.

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Systemic therapy in patients with severe rosacea

Bakhlykova¹,

Филимонкова²,

Matusevich³

2016

Vestnik dermatologii i venerologii

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Methods of rosacea treatment to achieve stable remission in a megalopolis

Vilochkina,

Lindover,

Galukhina

et al. 2024

Medicinskij sovet

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The review article is devoted to the aspects of rosacea therapy in a megalopolis, where a dermatological service is widely developed and it is possible to provide modern diagnostic, therapeutic and preventive measures. Rosacea negatively affects the emotional state of patients, and low awareness of chronic dermatoses often leads to self-medication and skin deterioration. The pathogenetic mechanisms of the disease have not been fully studied. Both genetic predisposition and environmental factors contribute to the occurrence of rosacea. A number of studies confirm that the triggers can be ultraviolet radiation, stress, intense physical activity, temperature changes, dietary characteristics, imbalance of the intestinal microbiota, alcohol consumption. Every day, residents of megalopolises face a combination of these factors, which combined with genetically determined features of the epidermal barrier and immune function, makes them more susceptible to rosacea and other skin diseases. The multifactorial nature of rosacea causes a variety of treatment methods that must be individualized in accordance with the clinical picture of the disease. With mild to moderate rosacea, monotherapy with external drugs is effective – azelaic acid, brimonidine tartrate, ivermectin, metronidazole. For the treatment of severe forms of rosacea, it is advisable to prescribe systemic therapy from groups of retinoids and antibiotics. The results of numerous studies are presented that physiotherapy methods which are available in large cities increase the effectiveness of treatment by reducing erythema and telangiectasia, enhancing repair and microcirculation in the epidermis. The accumulated experience of Russian dermatologists and foreign colleagues allows to determine the most effective combinations of treatment methods to achieve stable remission in patients.

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Experience in the use of isotretinoin in patients with rosacea fulminans (clinical case)

Cited by 2 publications

References 21 publications

Systemic therapy in patients with severe rosacea

Systemic therapy in patients with severe rosacea

Methods of rosacea treatment to achieve stable remission in a megalopolis

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