Experience with autologous pericardial patch closure of ventricular septal defect

Okwulehie, V; Dharmapuram, Anil Kumar; Swain, Santosh Kumar; Sundararaghavan, Sreekanthan; Kona, Samba Murthy

doi:10.1007/s12055-006-0004-3

Cited by 6 publications

(8 citation statements)

References 6 publications

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“…Regarding body weight of included patients it was 7.2± 3.2 Kg in group I and 7.8± 3.4 Kg in group II with no significant statistical difference. Azab et al [15] reported a higher body weight range 3 to 53 Kg mean of 12.14 ± 8.46 Kg. Again, Scully et al [14] reported median weight of 7 Kg (range, 2 to 66 Kg) this could explained by that they included adolescent patients in their study.…”

Section: Discussionmentioning

confidence: 95%

Comparative study between results of using synthetic versus pericardial patches for VSD closure in infants and children

Elsharkawy

El-Raouf

et al. 2022

ijhs

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Background: Generally ventricular septal defects (VSDs) are repaired with synthetic material: either Dacron (polyethylene terephthalate) or Goretex (expanded polytetrafluoroethylene) depending on surgeons preference. Aim of the work: To compare between the outcome of VSD closure by synthetic patches versus pericardial patches. Patients and methods: This study was conducted on 60 patients with surgical VSD closure. They were divided into 2 groups each included 30 patients. In group I synthetic patch (Dacron or Gortex) was used. In group II pericardial patch (fresh or treated or bovine) was used. The patients were evaluated at 3m and 6m after operation for: residual defects, endocarditis, heart block, AR, TR, LV dimensions and function and any other complications. Results: Ventilation time, was statistically significant shorter in group II (8.53 ± 6.37h) compared with Group I (30.60 ± 20.84h) p value 0.001*. Statistically significant shorter ICU time was found in group II (2.53 ± 0.90d) compared with group I (3.70 ± 1.62d). Twenty (66.7%) patients and 28(93.3%) patients in group I and II respectively had sinus rhythm. While 10 (33.3%) patients and 2 (6.7%) patients in group I and II respectively had temporary heart block.

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Section: Discussionmentioning

confidence: 95%

Comparative study between results of using synthetic versus pericardial patches for VSD closure in infants and children

Elsharkawy

El-Raouf

et al. 2022

ijhs

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“…Patch closure is conventionally performed with synthetic material such as Dacron or Gore-tex, which is readily available, and has the potential advantage of reducing the risk of residual VSD by stimulating fibrosis around the repair [ 15 ],[ 16 ]. Biological materials including glutaraldehyde treated autologous [ 16 ] and bovine pericardium [ 17 ] have also been less frequently used, however fresh pericardium is not recommended due to its potential to calcify, stretch and become aneurysmal over time. In this case, the location of the VSD just inferior to the moderator band provided minimal landing zone on which to secure a patch repair.…”

Section: Discussionmentioning

confidence: 99%

Late surgical repair of a traumatic ventricular septal defect

Harling

Ashrafian

Casula

et al. 2014

J Cardiothorac Surg

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Ventricular Septal Defect (VSD) complicates approximately 1-5% of patients presenting with penetrating chest trauma, however not all VSDs are evident at the time of initial presentation to the emergency department. Acute closure of traumatic VSDs is indicated in patients with a large defect and haemodynamic compromise, however closure may be delayed in smaller defects in order to minimise operative time, reduce operative mortality and allow for recovery from the initial trauma. We describe the case of a previously healthy 23 year-old Caucasian man who presented in extremis following stab wounds to the precordium. After emergency cardiopulmonary bypass and closure of lacerations to both the left and right ventricles, postoperative trans-thoracic echocardiography (TTE) noted a restrictive intramuscular VSD with a high velocity left to right shunt, initially managed conservatively. Elective surgical closure was performed 10 months after the initial injury through a right ventriculotomy using 4–0 Proline sutures reinforced with Teflon pledgets. Despite excellent clinical recovery, 3-month follow-up TTE noted a residual VSD in the mid apical septum. However, given the presence of minimal left to right shunt and the small size of the defect, the patient was managed conservatively with annual review and repeat transthoracic echo. This case highlights the potential pitfalls in both the diagnosis and management of traumatic VSDs particularly where the patient presents in extremis with other life-threatening injuries. Furthermore, it exemplifies the importance of a multidisciplinary approach when planning any elective intervention. Regardless of the management strategy, repeated re-assessment and re-evaluation is vital following penetrating cardiac trauma, and vigilant long-term follow-up is of paramount importance in these cases.Electronic supplementary materialThe online version of this article (doi:10.1186/s13019-014-0145-1) contains supplementary material, which is available to authorized users.

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“…The main side effect observed was the aneurysmal dilatation of the bioprosthetic tissue, which was demonstrated to be size-related to the patch itself (50). For equivalent considerations, correction of congenital septal defects using autologous and GA-treated heterologous pericardia might undergo the same post-surgery evolution (51)(52)(53). Schoof et al reported absent inflammation and tissue thickening of chemically untreated APPs, thanks to the progressive adaptation of the biomaterial (54).…”

Section: Congenital and Acquired Heart Defectsmentioning

confidence: 99%

Bioengineered tissue solutions for repair, correction and reconstruction in cardiovascular surgery

Iop¹,

Palmosi²,

Sasso³

et al. 2018

J. Thorac. Dis.

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The treatment of cardiac alterations is still nowadays a dramatic issue in the cardiosurgical practice. Synthetic materials applied in this surgery have failed in their long-term therapeutic efficacy due to low biocompatibility and compliance, especially when used in contractile sites. In order to overcome these treatment pitfalls, novel solutions have been developed based on biological tissues. Patches in pericardium, small intestinal submucosa, as well as engineered tissues of myocardium, heart valves and blood vessels have undergone a large preclinical investigation in regenerative medicine studies. Clinical translation has been started or reached by several of these new bioengineered treatment alternatives. This review will describe the preclinical and clinical experiences realized so far with the application of biological tissues in cardiovascular surgery. It will depict the progressive steps realized in the evolution of this research, as well as it will point out the challenges yet to face in order to generate the ideal biomaterial for cardiovascular repair, corrective and reconstructive surgery.

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Experience with autologous pericardial patch closure of ventricular septal defect

Cited by 6 publications

References 6 publications

Comparative study between results of using synthetic versus pericardial patches for VSD closure in infants and children

Comparative study between results of using synthetic versus pericardial patches for VSD closure in infants and children

Late surgical repair of a traumatic ventricular septal defect

Bioengineered tissue solutions for repair, correction and reconstruction in cardiovascular surgery

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