Experience With Mucosal Melanoma of the Nose and Paranasal Sinuses

Bridger, Andrew G.; Smee, David; Baldwin, Michael A.; Kwok, Bernard; Bridger, G. Patrick

doi:10.1111/j.1445-2197.2005.03343.x

Cited by 62 publications

(45 citation statements)

References 29 publications

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“…The same classification system was used previously for other nonepithelial skull base neoplasms, such as melanomas and soft tissue sarcomas. 18,19,[21][22][23] Staging for 121 patients (83%) was based on reported data and available information on orbital and intracranial extension (see Table 3). …”

Section: Primary Tumormentioning

confidence: 99%

Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: An international collaborative study

Gil

Patel

Singh

et al. 2007

Cancer

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BACKGROUND. Single‐institutional studies lack sufficient power to assess the role of surgery and radiotherapy in the management of sarcomas involving the anterior skull base. For this study, an international collaborative study group analyzed a large cohort of patients who underwent surgery for the treatment of skull base tumors. METHODS. A subset of 146 patients who had a histologic diagnosis of skull base sarcoma (SBS) formed the basis of this report. Most patients were aged ≥21 years (77%) and had stage IV disease (56%). Adjuvant radiotherapy was received by 35% of patients, and chemotherapy was received by 10% of patients. RESULTS. Orbital involvement was encountered in 53% of patients, involvement of the orbital wall was encountered in 46% of patients, and intracranial extension was encountered in 28% of patients. Positive microscopic margins were reported in 43% of patients (51 of 118 patients). Treatment‐related complications were reported in 27% of patients, and postoperative mortality was reported in 1.4% of patients. With a median follow‐up of 34 months, the 5‐year overall, disease‐specific, and recurrence‐free survival rates were 62%, 64%, and 57%, respectively. Tumor grade and adjuvant radiotherapy were not significant predictors of survival. Prior radiotherapy, intraorbital extension, positive margins, and postoperative complications were significant predictors of reduced disease‐specific survival on univariate analysis. The presence of positive/close margins, however, was the only independent predictor of poor overall, recurrence‐free, and disease‐specific survival on multivariate analysis (relative risk, 2.4; P = .006). The 5‐year disease‐specific survival rate was 77%, 43%, and 36% for patients with negative, close, and positive margins, respectively. CONCLUSIONS. The current results indicated that wide craniofacial resection with negative margins is an independent prognostic predictor of better outcome. Patients with positive margins have a high risk for tumor recurrence independent of tumor grade. Cancer 2007. © 2007 American Cancer Society.

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Section: Primary Tumormentioning

confidence: 99%

Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: An international collaborative study

Gil

Patel

Singh

et al. 2007

Cancer

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“…Cerrahiyle beraber RT ve KT yalnız veya beraber kullanılabilir. [1,7,[9][10][11][12] Radyoterapi ve/veya KT'nin cerrahi olmaksızın kullanımının genellikle cevap vermediği çalışmalarda gösterilmiştir. [1,6,7,12] Guzzo ve ark.…”

Section: Discussionunclassified

“…Benzer şekilde bir başka çalışmada da lokal nüks ortalama 14.7 ay saptanırken, metastaz görülme zamanının da ortalama 23.2 ay olduğu tespit edilmiştir. [11] Literatüre göre daha ileri yaşta malign melanom tanısı konulan hastamızın bulguları ve tümörün yerleşimi literatürle uyum göstermekteydi. Hastamızın yaşının ileri olması, nazofarinks ve kafa tabanı tutulumu olması nedeniyle cerrahi düşünülmeyerek kliniğimiz-de RT uygulandı.…”

Section: Discussionunclassified

Sinonasal tract primary mucosal malignant melanoma: Case report

Oruç¹,

Gül²,

Mayadağlı³

et al. 2012

J Kartal TR

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GirişMalign melanom sık görülen bir deri tümörüdür, deri melanomlarının %15-30'u baş ve boyun bölgesinde yer alır. Bununla beraber nazal kavite, paranazal sinüs-ler ve nazofarinksin (bu üç bölge sinonazal yol olarak da isimlendirilir) primer mukozal malign melanomları oldukça nadirdir. Tüm malign melanomların %0.3-2 oranında ve baş-boyun melanomlarının %4'ü oranın-da görülür.[1] Genel olarak kötü prognozlu bu tümör-lerin tedavisi de netlik kazanmamıştır. Cerrahiyle beraber radyoterapi (RT) ve/veya kemoterapi (KT) denenebilir. [2] Bu yazıda, onkoloji kliniğine burun tıkanıklığı ve kanaması şikayetiyle başvuran ve nazal kavitede malign melanom tanısı alan olgu, nadir görülmesi sebebiyle literatür eşliğinde sunuldu. Sinonazal Yol Primer Mukozal Malign

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“…5) ne alrededor del 1% del total de melanomas y entre un 3 y 4% del total de tumores de los senos paranasales. 2,3 Su incidencia estimada es de 1 por 500.000 habitantes por año. 3 Presenta una mayor propensión a afectar a mujeres y a pacientes por encima de 60 años.…”

Section: Discussionunclassified