Experiencing winter for spring flowering: A molecular epigenetic perspective on vernalization

Luo, Xiao; He, Yuehui

doi:10.1111/jipb.12896

Cited by 98 publications

(63 citation statements)

References 110 publications

(217 reference statements)

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“…Recently, in addition to the elucidation of the signal transduction mechanisms underlying abiotic stress responses, increased numbers of studies have shown important participation of epigenetic mechanisms in the response of plants to abiotic stresses (Sahu et al 2013; Kim et al 2015). A good example of epigenetic regulation in plant response to the environment is the extensive involvements of epigenetic marks in vernalization, a process where plants remember a prolonged low temperature exposure in the winter in order to flower in the spring (Zhao et al 2018; Luo and He 2020). The epigenetic mechanisms of cold‐dependent vernalization have been well documented and will not be discussed in this review.…”

Section: Introductionmentioning

confidence: 99%

“…Epigenetic mechanisms participate in the regulation of stress‐responsive genes at the transcriptional and posttranscriptional levels by altering the chromatin status of the genes. Stress treatments can cause changes in the chromatin modifications (Kim et al 2015; Lamke and Baurle 2017; Luo and He 2020). Moreover, epigenetic mechanisms play vital roles in the formation of stress memory, which may be inherited by the offspring of the stress‐treated plants (Friedrich et al 2019).…”

Section: Introductionmentioning

confidence: 99%

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Epigenetic regulation in plant abiotic stress responses

Chang

Jiang

et al. 2020

JIPB

341

225

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In eukaryotic cells, gene expression is greatly influenced by the dynamic chromatin environment. Epigenetic mechanisms, including covalent modifications to DNA and histone tails and the accessibility of chromatin, create various chromatin states for stress-responsive gene expression that is important for adaptation to harsh environmental conditions. Recent studies have revealed that many epigenetic factors participate in abiotic stress responses, and various chromatin modifications are changed when plants are exposed to stressful environments. In this review, we summarize recent progress on the cross-talk between abiotic stress response pathways and epigenetic regulatory pathways in plants. Our review focuses on epigenetic regulation of plant responses to extreme temperatures, drought, salinity, the stress hormone abscisic acid, nutrient limitations and ultraviolet stress, and on epigenetic mechanisms of stress memory.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epigenetic regulation in plant abiotic stress responses

Chang

Jiang

et al. 2020

JIPB

341

225

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“…2d), suggesting that the BAH-PHD-CPL2 complex acts in the same genetic pathway in flowering time control. In Arabidopsis, FLC, which is a MADS-box transcription factor that integrates multiple flowering signals, acts as a key floral repressor 31,43,44 . FLC directly represses the expression of florigen gene FT and SUPPRESSOR OF OVEREXPRESSION OF CO 1(SOC1) by binding to the promoter of SOC1 and the first intron of FT 45 .…”

Section: The Bah-phd-cpl2 Complex Represses Flowering By Inhibiting Fmentioning

confidence: 99%

“…Among them, flowering control has been a paradigmatic model for PRC complexes-mediated transcriptional repression in plants. The H3K27me3 dynamics in the flowering repressor gene FLOWERING LOCUS C (FLC) and the florigen gene FLOWERING LOCUS T (FT) play essential roles in the flowering time control 31 , and the H3K27me3 regulators influence flowering time in different ways 27,28,29,32,33,34,35,36,37,38,39,40 . Here, we demonstrated that the BAH domain-containing protein ASI1-IMMUNOPRECIPITATED PROTEIN 3 (AIPP3) and two PHD domain-containing proteins AIPP2/PARALOG OF AIPP2 (PAIPP2) could form a BAH-PHD module to read H3K27me3 and unmethylated H3K4, respectively, and coordinate in implementing transcriptional repression of hundreds of genes, particularly those development and stress-responsive genes in Arabidopsis such as the florigen gene FT and the RNA silencing effector gene AGO5.…”

Section: Introductionmentioning

confidence: 99%

Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex inArabidopsis

Zhang

Yuan

Zhang³

et al. 2020

Preprint

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Histone 3 Lys 27 trimethylation (H3K27me3)-mediated epigenetic silencing plays a critical role in multiple biological processes. However, the H3K27me3 recognition and transcriptional repression mechanisms are only partially understood. Here, we report a new mechanism for H3K27me3 recognition and transcriptional repression. Our structural and biochemical data showed that the BAH domain protein AIPP3 and the PHD proteins AIPP2 and PAIPP2 cooperate to read H3K27me3 and unmodified H3K4 histone marks, respectively, in Arabidopsis. The BAH-PHD bivalent histone reader complex silences a substantial subset of H3K27me3-enriched loci, including a number of development and stress response-related genes such as the RNA silencing effector gene ARGONAUTE 5 (AGO5) and We found that the BAH-PHD module associates with CPL2, a plant-specific Pol II carboxyl terminal domain (CTD) phosphatase, to form the BAH-PHD-CPL2 complex (BPC) for transcriptional repression. The BPC complex represses transcription through CPL2-mediated CTD dephosphorylation, thereby causing inhibition of Pol II release from the transcriptional start site. Our work reveals a mechanism coupling H3K27me3 recognition with transcriptional repression through the alteration of Pol II phosphorylation states, thereby contributing to our understanding of the mechanism of H3K27me3-dependent silencing.

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“…These structural changes in chromatin are regulated by posttranslational modifications of histone, such as histone acetylation, methylation, ubiquitination, sumoylation, and phosphorylation. These modifications are accomplished by covalent modification of the N-terminal tails of core histones (Nathan et al, 2006;Sridhar et al, 2007;Luo and He, 2020). The structural change of chromatin mediated by histone acetylation is reversible and greatly influences the regulation of gene expression (Chen and Tian, 2007;Clapier and Cairns, 2009).…”

mentioning

confidence: 99%

The Histone-Modifying Complex PWR/HOS15/HD2C Epigenetically Regulates Cold Tolerance

et al. 2020

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Cold stress is a major environmental stress that severely affects plant growth and crop productivity. Arabidopsis (Arabidopsis thaliana) HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE15 (HOS15) is a substrate receptor of the CULLIN4based CLR4 ubiquitin E3 ligase complex, which epigenetically regulates cold tolerance by degrading HISTONE DEACETYLASE2C (HD2C) to switch from repressive to permissive chromatin structure in response to cold stress. In this study, we characterized a HOS15-binding protein, POWERDRESS (PWR), and analyzed its function in the cold stress response. PWR loss-of-function plants (pwr) showed lower expression of cold-regulated (COR) genes and sensitivity to freezing. PWR interacts with HD2C through HOS15, and cold-induced HD2C degradation by HOS15 is diminished in the pwr mutant. The association of HOS15 and HD2C to promoters of cold-responsive COR genes was dependent on PWR. Consistent with these observations, the high acetylation levels of histone H3 by cold-induced and HOS15-mediated HD2C degradation were significantly reduced in pwr under cold stress. PWR also interacts with C-repeat element-binding factor transcription factors to modulate their cold-induced binding to the promoter of COR genes. Collectively, our data signify that the PWR-HOS15-HD2C histone-modifying complex regulates the expression of COR genes and the freezing tolerance of plants. Cold stress is one of the major environmental factors that seriously limits the growth and productivity of plants. To overcome this constraint, plants have developed effective ways to increase resistance to cold stress and freezing. Cold acclimation is a process that increases freezing tolerance upon exposure to low but nonfreezing temperatures. This process involves the activation or expression of cold-regulated (COR) genes and consequent physiological and biochemical changes in response to cold stress (Guo et al., 2018; Ding et al., 2019). Over the past two decades, various effectors and regulators of stress signaling pathways have been identified (Guo et al., 2018; Liu et al., 2018b; Zhang et al., 2019; Tang et al., 2020). One of the best-characterized mechanisms is the C-REPEAT ELEMENT-BINDING FACTORS (CBFs; also known as DEHYDRATION RESPONSIVE ELEMENT-BINDING proteins [DREB]: CBF1/DREB1B, CBF2/DREB1C, and CBF3/DREB1A) transcription factor-dependent cold signaling pathway (Chinnusamy et al., 2007; Guo et al., 2018; Liu et al., 2018a). These CBF transcription factors are APETALA2-like DNAbinding domain proteins that bind to the conserved C-REPEAT ELEMENT/DEHYDRATION RESPONSIVE ELEMENT (CRT/DRE) on the promoter regions of COR genes, such as COR15A, COR47, and COR78, and induce

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Experiencing winter for spring flowering: A molecular epigenetic perspective on vernalization

Cited by 98 publications

References 110 publications

Epigenetic regulation in plant abiotic stress responses

Epigenetic regulation in plant abiotic stress responses

Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex inArabidopsis

The Histone-Modifying Complex PWR/HOS15/HD2C Epigenetically Regulates Cold Tolerance

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