Experimental Acute Pancreatitis in Dogs

Ofstad, E; Amundsen, E; Po, Hagen

doi:10.3109/00365526909180153

Cited by 27 publications

(5 citation statements)

References 2 publications

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“…Pancreatic ascites fluid given intravenously led to a sharp decrease in blood pressure in healthy dogs [33,34]. The reason for this effect was unknown, but it was proposed to be partly due to histamine [35,36]. In a similar experiment, ascites fluid given intraperitoneally also led to a decrease in blood pressure [37].…”

Section: Principle Of Minimizing Toxicitymentioning

confidence: 84%

Treatment of Acute Pancreatitis: An Attempted Historical Review

Lankisch¹

2010

Pancreatology

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Section: Principle Of Minimizing Toxicitymentioning

confidence: 84%

Treatment of Acute Pancreatitis: An Attempted Historical Review

Lankisch¹

2010

Pancreatology

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“…Substances released by the necrotic pancreas, such as trypsin, chymotrypsin, bradykinin, histamine, prostaglandin E, endotoxins, and bacteria, have also been shown to be associated with AKI development ( 32 ). For example, histamine in pancreatic exudates may cause increased vascular permeability, hypovolemia, and hypotension ( 33 ). Peritoneal lavage increases urine output in patients with AP and AKI, suggesting that dialysis removes the substances responsible for causing AKI ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

“…For example, histamine in pancreatic exudates may cause increased vascular permeability, hypovolemia, and hypotension ( 33 ). Peritoneal lavage increases urine output in patients with AP and AKI, suggesting that dialysis removes the substances responsible for causing AKI ( 33 ). Cytokines may be responsible for renal impairment.…”

Section: Discussionmentioning

confidence: 99%

“…TNF-α can also cause endothelial cells to produce IL-1β, IL-8, and IL-6, which can cause thrombosis, renal ischemia, and the production of oxygen-free radicals ( 30 ). The urine N-acetyl-β-glucosidase to Cr ratio and early serum PLA2 activity are positively correlated in patients with AP, indicating that PLA2 may hydrolyze renal tubular epithelial cell membranes and result in AKI ( 33 ). Mucosal permeability is increased by inflammatory mediators that cause endotoxins and bacteria to move out of the colon.…”

Section: Discussionmentioning

confidence: 99%

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Association between serum creatinine to albumin ratio and short- and long-term all-cause mortality in patients with acute pancreatitis admitted to the intensive care unit: a retrospective analysis based on the MIMIC-IV database

Wang,

Li,

Luo

et al. 2024

Front. Immunol.

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BackgroundSerum creatinine (Cr) and albumin (Alb) are important predictors of mortality in individuals with various diseases, including acute pancreatitis (AP). However, most previous studies have only examined the relationship between single Cr or Alb levels and the prognosis of patients with AP. To our knowledge, the association between short- and long-term all-cause mortality in patients with AP and the blood creatinine to albumin ratio (CAR) has not been investigated. Therefore, this study aimed to evaluate the short- and long-term relationships between CAR and all-cause mortality in patients with AP.MethodsWe conducted a retrospective study utilizing data from the Medical Information Market for Intensive Care (MIMIC-IV) database. The study involved analyzing various mortality variables and obtaining CAR values at the time of admission. The X-tile software was used to determine the optimal threshold for the CAR. Kaplan-Meier (K-M) survival curves and multivariate Cox proportional hazards regression models were used to assess the relationship between CAR and both short- and long-term all-cause mortality. The predictive power, sensitivity, specificity, and area under the curve (AUC) of CAR for short- and long-term mortality in patients with AP after hospital admission were investigated using Receiver Operating Characteristic analysis. Additionally, subgroup analyses were conducted.ResultsA total of 520 participants were included in this study. The CAR ideal threshold, determined by X-tile software, was 0.446. The Cox proportional hazards model revealed an independent association between CAR≥0.446 and all-cause mortality at 7-day (d), 14-d, 21-d, 28-d, 90-d, and 1-year (y) before and after adjustment for confounders. K-M survival curves showed that patients with CAR≥0.446 had lower survival rates at 7-d, 14-d, 21-d, 28-d, 90-d, and 1-y. Additionally, CAR demonstrated superior performance, with higher AUC values than Cr, Alb, serum total calcium, Glasgow Coma Scale, Systemic Inflammatory Response Syndrome score, and Sepsis-related Organ Failure Assessment score at 7-d, 14-d, 21-d, 28-d, 90-d, and 1-y intervals. Subgroup analyses showed that CAR did not interact with a majority of subgroups.ConclusionThe CAR can serve as an independent predictor for short- and long-term all-cause mortality in patients with AP. This study enhances our understanding of the association between serum-based biomarkers and the prognosis of patients with AP.

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“…Pancreatic ascites fluid given intravenously led to a sharp decrease in blood pressure in healthy dogs[2829]. The reason for this effect was unknown, but it was proposed to be partly due to histamine[3031]. In a similar experiment, ascites fluid given intraperitoneally also led to a decrease in blood pressure[32].…”

Section: Acute Pancreatitis In 20th Centurymentioning

confidence: 99%

Clinical pancreatology I: Pancreatic medical history

Andrén‐Sandberg¹

2010

NAJMS

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The present article and subsequent reviews will not be to report all what has been published, but rather to give an introduction samples that hopefully make the reader eager to read the whole article or articles with “a taste of clinical pancreatology in 2010”. The main sources of literatures were PubMed, and the additional Journals such as Pancreas, Pancreatology and Journal of the Pancreas were also scrutinized. Only some full articles in almost all languages were included in the review, other articles, however, that were too superficial or too poor in other ways, were omitted, and the publications of non-human study were excluded.

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Experimental Acute Pancreatitis in Dogs

Cited by 27 publications

References 2 publications

Treatment of Acute Pancreatitis: An Attempted Historical Review

Treatment of Acute Pancreatitis: An Attempted Historical Review

Association between serum creatinine to albumin ratio and short- and long-term all-cause mortality in patients with acute pancreatitis admitted to the intensive care unit: a retrospective analysis based on the MIMIC-IV database

Clinical pancreatology I: Pancreatic medical history

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