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Antimicrobial prophylaxis with agents active against aerobic and anaerobic micro-organisms leads to a significant reduction of infectious complications following colorectal surgery. A single dose (1600 mg) of tinidazole (a nitroimidazole derivate) and doxycycline (400 mg) will provide serum and tissue values well above minimum inhibitory concentration (MIC) values for more than 24 hours. To reduce the unwanted side effects and cost of prolonged antimicrobial prophylaxis, a prospective controlled clinical multicenter study comparing the effect of a single dose before operation of tinidazole and doxycycline to five days of prophylaxis before operation in 234 patients undergoing elective colorectal surgery was undertaken. Six patients given a single dose of prophylaxis before operation (n = 118) developed infectious complication (5.1%). Prolongation of prophylaxis before operation for four days after operation (n = 116) did not lead to any further reduction of infectious complications. A single dose of tinidazole and doxycycline before operation is a simple and effective prophylaxis against infectious complications following elective colorectal surgery.

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GJONE, E., OFSTAD, E., MARTON, P. F. & AMUNDSEN, E. Phospholipase Activity in Pancreatic Exudate in Experimental Acute Pancreatitis. Scund. J. Gusfroenr. 2, 181-185, 1967. Acute pancreatitis was induced in dogs by injecting into the pancreatic duct a mixture of taurocholate and trypsin. Exudate from pancreas was collected outside the body by a special technique in separate portions each covering one hour. All exudates were found to possess ability to break down lecithin by phospholipase and lysophospholipase action. Calcium, bile, and taurocholate stimulated and EDTA inhibited the degradation of lecithin. The phospholipase activity was studied in the hourly collected portions of pancreatic exudate. It was very high and had a maximum in the portion collected during the first hour, being lower and levelling out in the portions collected during the 4 to 7 hour periods. Amylase activity paralleled the phospholipase activity of the exudate. The demonstration of an early release in acute pancreatitis of lecithin-hydrolyzing enzyme systems in pancreatic exudate may have bearings on the pathogenesis of acute pancreatitis.Scand J Gastroenterol Downloaded from informahealthcare.com by University of Auckland on 11/18/14For personal use only.

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