Experimental allergic sialgadenitis VIII. Acute parotitis following intraductal instillation of antiserum to salivary antigens in the rat

Sela, J.; Bab, J. A.; Rosenmann, E.; Boss, J. H.

doi:10.1002/path.1711190302

Cited by 5 publications

(1 citation statement)

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“…Experimental allergic sialoadenitis has been investi gated to explain the pathogenesis of certain inflamma tory processes of the salivary glands such as Sjogren's disease. Although several models of experimental sialoadenitis induced by various immunological methods in rats have been reported by a group of authors in Israel (1)(2)(3)(4)(5)(6)(7)(8), the lack of chemotactic activity of leuko triene B4 (LTB4) for the rat neutrophil raises questions about the usefulness of rats in the screening of anti-in flammatory agents for potential use in the treatment of human disease (9). In this report, we showed easy methods for inducing both acute and chronic ex perimental allergic sialoadenitis in guinea pigs with a high incidence.…”

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Experimental Models of Acute and Chronic Sialoadenitis in the Guinea Pig.

Miyazawa¹,

Mikami

Miyasaka

et al. 1992

Jpn.J.Pharmacol

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Acute and chronic sialoadenitis were induced in ovalbumin-immunized guinea pigs by a single or repeated (once a day for 5 days) instillation of antigen into the parotid gland via the parotid duct. The acute sialoadenitis was characterized by infiltration of inflammatory polymorphonuclear leukocytes and the chronic one, by extensive tissue destruction together with infiltration of mononu clear leukocytes. In acute sialoadenitis, myeloperoxidase activity in the parotid gland, which was a mark er of accumulation of neutrophils, was elevated, but in the chronic stage, it returned nearly to the con trol level. This observation is in accord with the histological findings that infiltrating cells in acute and chronic sialoadenitis were mainly polymorphonuclear and mononuclear leukocytes, respectively. Although cyclophosphamide suppressed the inflammation, both in acute and chronic sialoadenitis, in domethacin exerted its anti-inflammatory effect only in the acute stage. Our experimental models of acute and chronic sialoadenitis were easy to prepare, and had a high incidence. As the typical features of inflammatory development from acute to chronic phases were observed in these models, these mod els may be useful for studying the mechanism of the chronic course in immunologically induced in flammation and the effects of drugs on each phase and the chronic course of inflammation.

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confidence: 99%