The wide application of evaporative cooling techniques in which the optimization criteria form the theoretical basis for improving evaporative cooling performance is essential for energy conservation and emission reduction. Based on exergy analysis and the entransy dissipation-based thermal resistance method, this contribution aims to investigate the effects of flow and area distributions in the optimization of the performance of indirect evaporative cooling systems. We first establish the relationships of exergy efficiency, entransy dissipation-based thermal resistance and cooling capacity of a typical indirect cooling system. Using the prescribed inlet parameters, the heat and mass transfer coefficients and the circulating water mass flow rate, we then numerically validate that when the cooling capacity reaches a maximum, the entransy dissipation-based thermal resistance falls to a minimum while the exergy efficiency is not at an extreme value. The result shows that the entransy dissipation-based thermal resistance, not the exergy efficiency, characterizes the heat transfer performance of an evaporative cooling system, which provides a more suitable method for evaluating and analyzing the indirect cooling system. indirect evaporative cooling, optimization criteria, entransy dissipation-based thermal resistance, exergy efficiency Citation: Yuan F, Chen Q. Optimization criteria for the performance of heat and mass transfer in indirect evaporative cooling systems. Chin Sci Bull, 2012, 57: 687693,Evaporative cooling is a technique in which unsaturated moist air is in contact with water, causing liquid water evaporation resulting in low temperature water or wind. Since the ambient air is clean and low cost, evaporative cooling is the focus of wide interest and applications. Many scientists have undertaken a large amount of research on evaporative cooling systems, mainly on the following three aspects: (1) The analysis of the impact factors on the performance of evaporative cooling systems, such as temperature, humidity and the mass flow rate of moist air [1,2], temperature and the mass flow rate of water [3] and direct/ indirect evaporative cooling with different structures, such as plate types [4,5], tubular types [6,7] and heat pipes [8] etc.(2) The design and optimization of evaporative cooling cycles, including two-stage or three-stage combined direct/ indirect evaporative cooling [9,10] and combined liquid desiccant dehumidification and evaporative cooling [11]. (3) The performance analysis and optimization theory of evaporative cooling systems, with emphasis on exergy analysis [12,13]. In exergy theory, researchers always take exergy efficiency as an assessment index to analyze the exergy loss distribution of all irreversible processes in the system. This involves evaluating the performance of evaporative cooling, and seeking effective ways for improving the performance of evaporative cooling using the criterion that maximum exergy efficiency leads to optimal performance. However, the physical essence of exer...