Experimental and clinical evidence of physical exercise on BDNF and cognitive function: A comprehensive review from molecular basis to therapy

Dadkhah, Masoomeh; Saadat, Maryam; Ghorbanpour, Amir Mohammad; Kor, Nasroallah Moradi

doi:10.1016/j.bbii.2023.100017

Cited by 10 publications

(1 citation statement)

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“…The control of brain-derived neurotrophic factor (BDNF) levels, an important regulator of neurogenesis and synaptic plasticity, goes beyond just physical activity and involves an intricate combination of genetic, epigenetic, and environmental elements [75]. Recent developments in the fields of neurobiology and exercise physiology have revealed various ways in which BDNF expression is controlled such as through the activation of internal signaling pathways, the adjustment of neurotransmitter systems, and an enhancement of neurovascular coupling [76]. Although studies have shown varying results on the immediate drop in BDNF levels after exercise, the overall increase from regular physical activity highlights the flexible regulation of BDNF [77,78].…”

Section: Preserving Cognitive Functionmentioning

confidence: 99%

The Role of Physical Activity in Adjunctive Nursing Management of Neuro-Degenerative Diseases among Older Adults: A Systematic Review of Interventional Studies

Alanazi

2024

Life

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Neurodegenerative diseases such as dementia and Parkinson’s disease pose significant challenges to older adults globally. While pharmacological treatments remain primary, increasing evidence supports the role of non-pharmacological strategies like physical activity in managing these conditions. This systematic review critically evaluates the effectiveness of Nursing based physical activity interventions in improving cognitive function, physical functioning, mobility, and overall quality of life among older adults with neurodegenerative diseases. We conducted a comprehensive search across PubMed, EMBASE, Web of Science, CENTRAL, and other relevant databases, focusing on randomized controlled trials and observational studies that examined the impact of structured physical activity. Our findings from nineteen studies involving 1673 participants indicate that interventions ranging from aerobic exercises, resistance training, to mind-body exercises like Tai Chi and yoga have beneficial effects. Specifically, physical activity was consistently found to enhance cognitive performance, increase mobility, and improve balance and daily living activities, contributing to a better quality of life. However, these benefits vary depending on the type, intensity, and duration of the activity performed. Despite promising results, limitations such as small sample sizes, study heterogeneity, and short-term follow-up periods call for more robust, long-term studies to solidify these findings. This review underscores the potential of tailored physical activity programs as adjunctive therapy in the comprehensive management of neurodegenerative diseases among the elderly population.

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