Experimental and clinical study on the hypolipidemic and antisclerotic effect of Lactobacillus Bulgaricus strain GB N 1 (48)

Doncheva, Nadezhda Iv; Antov, G; Softova, E.; Nyagolov, Yuri

doi:10.1016/s0271-5317(01)00397-9

Cited by 8 publications

(4 citation statements)

References 11 publications

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“…Probiotics, by using hydroxy steroid dehydrogenase and conjugated bile acid hydrolase enzymes, break down the bile acid and hydrolyse bile salts ( 8 , 11 , 15 ) . By doing so, the enterohepatic circulation of bile acids will be disrupted ( 38 – 40 ) . Hydroxy methyl glutarate CoA (HMG CoA) is another compound that helps probiotics block HMG CoA reductase activity, which is a rate-limiting enzyme and is involved in the endogenous production of cholesterol.…”

Section: Discussionmentioning

confidence: 99%

The effects of probiotic and conventional yoghurt on lipid profile in women

et al. 2010

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Many studies have been done on the hypocholesterolaemic effect of probiotic yoghurt. The results, however, are not conclusive. The aim of the present study was to test the effect of probiotic and conventional yoghurt on the lipid profile in women. In a randomised trial, ninety female volunteers aged 19-49 years were assigned to three groups. Subjects consumed daily 300 g probiotic yoghurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 or 300 g conventional yoghurt or no yoghurt for 6 weeks. Fasting blood samples, 3 d dietary records and anthropometric measurements were collected at baseline (T1), end of week 3 (T2) and end of week 6 (T3). Lipid profile parameters were determined by enzymic methods. Results showed no significant difference in lipid profile within any group throughout the study. Comparing mean differences (T1 2 T3) among the three groups showed: no difference in TAG and LDL-cholesterol, a decrease in cholesterol in both conventional (P,0·05) and probiotic yoghurt groups (P,0·005) compared with the control group, a decrease in total:HDL-cholesterol ratio for conventional (P,0·05) and probiotic yoghurt groups (P,0·001) compared with the control group, and an increase in HDL-cholesterol in the probiotic yoghurt group (P, 0·05) compared with the control group. Positive changes in lipid profile were observed in both yoghurt groups. Any added effect, therefore, is due to the consumption of fermented milk products.Probiotic yoghurt: Lipid profile: Women

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Section: Discussionmentioning

confidence: 99%

The effects of probiotic and conventional yoghurt on lipid profile in women

et al. 2010

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“…However, there is little evidence that probiotic bacteria are able to reduce serum cholesterol in vivo. Most studies investigated the cholesterol-lowering effect in hypercholesterolaemic patients or after a high-fat diet (Bertolami et al, 1999;Kawase et al, 2001;Doncheva et al, 2002;Abd El-Gawad et al, 2005). There are few reports documenting the influence on normocholesterolaemic subjects (De Roos et al, 1999;Jahreis et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 modulate unspecific cellular immune response in healthy adults

Friedrich²,

et al. 2007

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Objective: It was determined whether a combination of Lactobacillus acidophilus (L. acidophilus) 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 (B. lactis 420) affect the faecal microbiota as well as immunological parameters and blood lipids in healthy adults. Design: A placebo-controlled, double-blinded, randomized crossover trial was conducted. Subjects: Twenty-six healthy volunteers (mean age 25 years) were recruited by advertising in academical buildings. All of them completed the study. Methods: After 3-week run-in period, half of the volunteers consumed 300 g/day of yoghurt supplement containing probiotic strains L. acidophilus 74-2 and B. lactis 420, and the other half received the placebo product for a period of 5 weeks. The two groups were crossed during the following 5-week period. Blood and faecal samples were collected at the end of each period. The faecal content of probiotic bacteria, faecal short-chain fatty acids (SCFA), serum lipids and plasma immune system biomarkers were evaluated. Results: Faecal proportions of L. acidophilus and of B. lactis increased significantly from 0.02 to 0.19 and 0.4 to 1.4% (Po0.05), respectively. Percentages of granulocytes and monocytes showing phagocytic activity were significantly elevated from 92 to 95% during probiotic intervention, whereas their oxidative burst activity and specific immune parameters remained unaffected. Fecal SCFA and serum cholesterol levels were not influenced by the probiotics. However, serum concentrations of triacylglyceroles decreased significantly by 11.6% (Po0.05) in the probiotic supplementation period. Conclusions: L. acidophilus and B. lactis were recovered in faeces in significantly elevated numbers after supplementation. They are able to modulate unspecific cellular immune response indicated by the increased phagocytic activity.

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“…Various strains of probiotic LAB breakdown bile acids and hydrolyze bile salts by means of hydroxy steroid dehydrogenase and BSH. This interrupts the enterohepatic circulation of bile acids [93][94][95].…”

Section: Low-density Lipoprotein (Ldl)mentioning

confidence: 99%