The effects of probiotic and conventional yoghurt on lipid profile in women

Sadrzadeh-Yeganeh, Haleh; Elmadfa, Ibrahim; Djazayery, A; Jalali, Mahmoud; Heshmat, Ramin; Chamary, Maryam

doi:10.1017/s0007114509993801

Cited by 161 publications

(105 citation statements)

References 31 publications

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“…Specific bacterial taxa have been determined to improve lipid markers in the host. Bifidobacteria, which showed positive associations with plasma HDL cholesterol in our previous study (15), have been identified to alleviate dyslipidemia and high-fat-induced insulin resistance when administered as probiotics (46)(47)(48)(49)(50). In addition, some changes in gut microbiota composition induced through host factors might still have pathological consequences, as shown recently for a fat-induced pathobiont expansion caused by changes in the bile acid pool (38).…”

Section: Figmentioning

confidence: 53%

Diet-Induced Alterations of Host Cholesterol Metabolism Are Likely To Affect the Gut Microbiota Composition in Hamsters

Martínez

Perdicaro

Brown

et al. 2013

Appl Environ Microbiol

192

122

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The gastrointestinal microbiota affects the metabolism of the mammalian host and has consequences for health. However, the complexity of gut microbial communities and host metabolic pathways make functional connections difficult to unravel, especially in terms of causation. In this study, we have characterized the fecal microbiota of hamsters whose cholesterol metabolism was extensively modulated by the dietary addition of plant sterol esters (PSE). PSE intake induced dramatic shifts in the fecal microbiota, reducing several bacterial taxa within the families Coriobacteriaceae and Erysipelotrichaceae. The abundance of these taxa displayed remarkably high correlations with host cholesterol metabolites. Most importantly, the associations between several bacterial taxa with fecal and biliary cholesterol excretion showed an almost perfect fit to a sigmoidal nonlinear model of bacterial inhibition, suggesting that host cholesterol excretion can shape microbiota structure through the antibacterial action of cholesterol. In vitro experiments suggested a modest antibacterial effect of cholesterol, and especially of cholesteryl-linoleate, but not plant sterols when included in model bile micelles. The findings obtained in this study are relevant to our understanding of gut microbiota-host lipid metabolism interactions, as they provide the first evidence for a role of cholesterol excreted with the bile as a relevant host factor that modulates the gut microbiota. The findings further suggest that the connections between Coriobacteriaceae and Erysipelotrichaceae and host lipid metabolism, which have been observed in several studies, could be caused by a metabolic phenotype of the host (cholesterol excretion) affecting the gut microbiota.T he mammalian gastrointestinal tract is colonized by trillions of microorganisms (the gut microbiota), a large fraction of which are bacteria. This microbial community has an extensive impact on host metabolism with important implications for health (1-3). The contribution of the gut microbiota to energy harvest from the diet and to fat storage constitutes a key beneficial trait that underlies host-microbiota symbiosis in mammals (4). However, this contribution has likely become detrimental to modern humans living in societies with excess food resources, as it increases susceptibility to metabolic disorders, such as obesity, type 2 diabetes, and coronary heart disease. Accordingly, the gut microbiota is increasingly being accepted as an important factor that contributes to pathological conditions associated with obesity (5), and in humans, metabolic pathologies often are associated with alterations in the gut microbiota (which is referred to as dysbiosis) (6-9). Unfortunately, there is still little consensus on the bacterial groups that are linked to obesity-related diseases and metabolic phenotypes (3). In addition, although comparisons between germ-free and conventional mice and rats have clearly established a role of the microbiota in modulating host lipid metabolism (2, 10-12), it remai...

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Section: Figmentioning

confidence: 53%

Diet-Induced Alterations of Host Cholesterol Metabolism Are Likely To Affect the Gut Microbiota Composition in Hamsters

Martínez

Perdicaro

Brown

et al. 2013

Appl Environ Microbiol

192

122

View full text Add to dashboard Cite

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“…One of the possible mechanisms by which this effect occurs is through the impact of probiotics on changing intestinal microbiota [8,43]. Probiotic consumption can balance intestinal microbiota for people with T2DM, which might have been caused by the short-chain fatty acids (SCFA) produced from probiotic consumption [44]. Probiotics were effective in suppressing the progression of streptozotocin-induced diabetes [42], in that streptozotocin has the ability to selectively kill pancreatic β-cells, which can decrease endogenous insulin release and increase glucose intolerance [45].…”

Section: Discussionmentioning

confidence: 99%

Multiple effects of probiotics on different types of diabetes: a systematic review and meta-analysis of randomized, placebo-controlled trials

Wang

Juan

et al. 2017

Journal of Pediatric Endocrinology and Metabolism

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Background: A systematic review and meta-analysis was designed to evaluate the effect of probiotics on diabetes and its associated risk factors. Methods: We systematically searched the Cochrane Library, PubMed, EMBASE and Web of Science to June 2016. We also hand-searched the citation lists of included studies and previously identified systematic reviews to identify further relevant trials. Our primary outcome variables included glucose, glycated hemoglobin (HbA 1c ) and insulin. The pooled standardized mean difference was used to compare the effect between the probiotics and controlled groups, and the pooled standardized mean difference effect size with a 95% confidence interval (CI) was estimated using a random-effect model. Heterogeneity was assessed with Cochran's Q and Higgins I 2 tests. Two reviewers assessed trial quality and extracted data independently. The analysis and bias for each included study was performed and assessed using Review Manager 5.2. Results: Eighteen randomized, placebo-controlled studies (n = 1056 participants, 527 consuming probiotics, 529 not consuming probiotics) were included for analysis. Comparing the probiotics groups with the control groups, there were statistically significant pooled standardized

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“…Yoğurt feeding was associated with a clinically relevant decrease in stool frequency and duration of diarrhea in children who have reducing sugars in stools [24]. Positive changes in lipid profile were observed in both yoğurt groups [25].…”

Section: A Cultural Product Related To Probiotics: Yogurt (Yoğurt)mentioning

confidence: 88%

Probiotics for Autoimmune Diseases: Is There a Benefit?

Özdemir¹,

Göksu-Erol²

2012

Contemporary Pediatrics

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The effects of probiotic and conventional yoghurt on lipid profile in women

Cited by 161 publications

References 31 publications

Diet-Induced Alterations of Host Cholesterol Metabolism Are Likely To Affect the Gut Microbiota Composition in Hamsters

Diet-Induced Alterations of Host Cholesterol Metabolism Are Likely To Affect the Gut Microbiota Composition in Hamsters

Multiple effects of probiotics on different types of diabetes: a systematic review and meta-analysis of randomized, placebo-controlled trials

Probiotics for Autoimmune Diseases: Is There a Benefit?

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