Experimental and idiopathic siderosis in cats

Functional Study of Exocrine Pancreas in Idiopathic Hemochromatosis, Untreated and Treated by Venesections

“…After the initial work of Taylor et al [34] showing the role of pancreatic insuffi ciency in iron absorption, isotopic methods have given discordant conclu sions. Certain authors [5,10,27] observe in external pancreatic insufficiency, and eventually in cirrhosis and hemochromatosis, an increased iron absorp tion which is reduced by the administration of pancreatic extracts.…”

Absorption of Iron in Cirrhosis of Liver

“…None had any evidence of pancreatic calcification. (Taylor et al, 1935;Gillman et al, 1947;Kinney et al, 1950Kinney et al, , 1955 (Pitcher, 1962). In alcoholic subjects the intake of iron is increased owing to the iron content of alcoholic beverages.…”

“…None had any evidence of pancreatic calcification. (Taylor et al, 1935;Gillman et al, 1947;Kinney et al, 1950Kinney et al, , 1955. Davis and Badenoch (1962) have corroborated these findings in human pancreatic disease.…”

Effect of the exocrine pancreatic secretions on iron absorption.

“…There is a considerable body of evidence indicating that deficiency of the pancreatic secretions leads to excessive absorption of iron, and consists of observations both in experimental animals and in human subjects. The animal evidence includes the increase in carcass iron observed after pancreatectomy (Taylor, Stiven, and Reid, 1931), after ligation of the pancreatic duct (Taylor, Stiven, and Reid, 1935;Gillman, Gillman, Mandelstam, and Gilbert, 1947;Kinney, Finch, Kaufman, Hegsted, and Partington, 1950), and after pancreatic necrosis induced by ethionine (Kinney, Kaufman, and Klavins, 1955;Brozovic, Popovi6, Obradovic, and Pendid, 1966), or by protein malnutrition (Kaufman, Klavins, and Kinney, 1958). Similar observations have been reported in patients with pancreatic disease.…”