We reviewed 246 colonic biopsy specimens. Biopsy specimens were fixed in formaldehyde, embedded in paraffin wax, step-sectioned at 4 jum, and stained with haematoxylin and eosin and periodic acid-Schiff. At least 10 serial sec-

Following a study of the exocrine pancreas based on duodenal intubation in 32 cases of hemochromatosis (22 untreated and 10 treated), the principal findings are as follows: normal absence of noteworthy disturbance of lipase secretion after CCK; in the untreated group, by comparison with the control subjects and with alcoholic cirrhosis, considerable increase in the volume of duodenal juice collected after secretin, with low concentration but high flow of bicarbonates; absence of hypersecretion in the treated group whose secretory pattern tends to become identical to that of the control subjects.

The arrhythmogenic action of epinephrine was studied in 3 groups of rats: 10 rats with mild constriction of the abdominal aorta (group H1), 10 rats with severe constriction (group H2), 10 sham-operated age-matched rats (group C). Blood pressure and ECG were recorded before, during and after 5 min. perfusion of increasing doses of epinephrine (1, 5, 10 and 25 micrograms.kg-1.min.-1). Ventricular arrhythmia was evaluated from the ECG using a modified Lown's grading system. The ventricular hypertrophy index was calculated from the heart/body weight ratio (mg/g). The mean arterial blood pressure was significantly higher in groups H1 and H2 than in the control group. The ventricular hypertrophy was significant in group H2, but not in group H1. There was no significant difference between the amplitudes of the epinephrine-induced hypertensive responses in the 3 groups but the extent of arrhythmia was significantly lower in the animals with high hypertrophy index.

No abstract