Experimental and natural infection of early weaned pigs with Salmonella choleraesuis

Anderson, Robin C.; Nisbet, David J.; Buckley, Sandra A.; Genovese, Kenneth J.; Harvey, Roger B.; DeLoach, John R.; Keith, N. K.; Stanker, Larry H.

doi:10.1016/s0034-5288(98)90136-9

Cited by 23 publications

(19 citation statements)

References 5 publications

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“…Infection is thought to be by oral ingestion or by inhalation. Experimental and natural infections with Choleraesuis in pigs support this hypothesis [99,107,108]. Infected animals showed positive faecal, tonsil, and nasal swabs for up to 4 weeks following infection and shed sufficient numbers of bacteria to infect naturally exposed pigs.…”

Section: Choleraesuismentioning

confidence: 95%

Host adapted serotypes of Salmonella enterica

et al. 2000

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Salmonella constitutes a genus of zoonotic bacteria of worldwide economic and health importance. The current view of salmonella taxonomy assigns the members of this genus to two species: S. enterica and S. bongori. S. enterica itself is divided into six subspecies, enterica, salamae, arizonae, diarizonae, indica, and houtenae, also known as subspecies I, II, IIIa, IIIb, IV, and VI, respectively [1]. Members of Salmonella enterica subspecies enterica are mainly associated with warm-blooded vertebrates and are usually transmitted by ingestion of food or water contaminated by infected faeces. The pathogenicity of most of the distinct serotypes remains undefined, and even within the most common serotypes, many questions remain to be answered regarding the interactions between the organism and the infected host.Salmonellosis manifests itself in three major forms: enteritis, septicaemia, and abortion, each of which may be present singly or in combination, depending on both the serotype and the host involved. Although currently over 2300 serovars of Salmonella are recognized, only about 50 serotypes are isolated in any significant numbers as human or animal pathogens [2, 3] and they all belong to subspecies enterica. Of these, most cause acute gastroenteritis characterized by a short incubation period and a severe systemic disease in man or animals, characterized by septicaemia, fever and/or abortion, and such serotypes are often associated with one or few host species [4–6].It is the intention of this review to present a summary of current knowledge of these host-adapted serotypes of S. enterica. The taxonomic relationships between the serotypes will be discussed together with a comparison of the pathology and pathogenesis of the disease that they cause in their natural host(s). Since much of our knowledge on salmonellosis is based on the results of work on Typhimurium, this serotype will often be used as the baseline in discussion. It is hoped that an appreciation of the differences that exist in the way these serotypes interact with the host will lead to a greater understanding of the complex host–parasite relationship that characterizes salmonella infections.

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Section: Choleraesuismentioning

confidence: 95%

Host adapted serotypes of Salmonella enterica

et al. 2000

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“…Salmonella choleraesuis was not recovered from ileocolic lymph tissue, which is surprising because culture of these specimens is thought to typically yield the best chance of recovering Salmonella from infected pigs. 1,[5][6][7] Of the Salmonella-positive specimens, all but 2 were obtained from the 6 nontransported pigs (Table 1), which is again contrary to expectation. The relatively short posttransit sampling interval in this study (Ͻ24 hours) may have been insufficient to allow for proliferation of salmonellae in response to the suspected transportation stress.…”

mentioning

confidence: 87%

Assessment of the Long-Term Shedding Pattern ofSalmonellaSerovarCholeraesuisFollowing Experimental Infection of Neonatal Piglets

et al. 2000

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In the United States, swine salmonellosis is most often attributed to infections by Salmonella serovar choleraesuis. As a host-adapted pathogen rarely found in nonswine sources, S. choleraesuis is thought to be spread primarily via horizontal transmission, with carrier animals playing an important role. Little has been reported regarding infection of neonatal piglets, particularly regarding their potential to become carriers. Evidence reported herein demonstrates that piglets experimentally infected by S. choleraesuis at 2 days of age were capable of shedding the pathogen for up to 85 days postinfection, at which time the study was concluded. This study also presents findings supporting the use of GN-Hajna as a preenrichment medium for the isolation of S. choleraesuis.

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“…Serotype Choleraesuis is highly host adapted to pigs (52,154). A pig model of experimental and natural infection of weaning pigs with serotype Choleraesuis has been developed (6). In this model, infection by oral inoculation of 10 8 CFU of serotype Choleraesuis was established, as indicated by an acute illness as well as by recovery of the organism from ileocolic lymph nodes collected at necropsy 7 days postchallenge (6).…”

Section: Host Defensementioning

confidence: 99%

“…A pig model of experimental and natural infection of weaning pigs with serotype Choleraesuis has been developed (6). In this model, infection by oral inoculation of 10 8 CFU of serotype Choleraesuis was established, as indicated by an acute illness as well as by recovery of the organism from ileocolic lymph nodes collected at necropsy 7 days postchallenge (6). Serotype Choleraesuis appears to colonize and invade the intestinal epithelium, disseminate to peripheral organs, and cause septicemia in pigs, as does serotype Typhimurium in mice (6,44,116).…”

Section: Host Defensementioning

confidence: 99%

“…In this model, infection by oral inoculation of 10 8 CFU of serotype Choleraesuis was established, as indicated by an acute illness as well as by recovery of the organism from ileocolic lymph nodes collected at necropsy 7 days postchallenge (6). Serotype Choleraesuis appears to colonize and invade the intestinal epithelium, disseminate to peripheral organs, and cause septicemia in pigs, as does serotype Typhimurium in mice (6,44,116). As with serotype Typhimurium, histologically serotype Choleraesuis revealed a predilection for the mucosa of the colon and the luminal surface of ileal M cells of Peyer's patches (113).…”

Section: Host Defensementioning

confidence: 99%

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