Experimental and numerical investigation on particle–particle interaction of multi-particle separation in an alternating and repetitive microchannel

Çadırcı, Sertaç; Ince, D.; Ghanem, I.; Birol, Semra Zuhal; Trabzon, Levent; Turhan, Hamza

doi:10.1007/s00542-018-3965-4

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…Figure 4(a) shows that the bandwidth of 2 µm particle was relatively small at 1 and 3 µl min −1 , but it rapidly increased when the total flow rate was changed from 5 to 20 µl min −1 . This might be caused by the increasing driving forces and the collision effect between particles [42]. Based on the equations ( 1)-( 4), it can be obtained that the driving force became strong with the increase of the flow rate.…”

Section: Resultsmentioning

confidence: 99%

Continuous elasto-inertial separation of microparticles using a co-flowing Newtonian-viscoelastic fluid system

Fan¹,

Zhao²,

Wu³

et al. 2019

J. Micromech. Microeng.

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A new method for continuous separation of microparticles in viscoelastic fluid is reported. A series of sharp corners were fabricated at one side of a microchannel, which induced the curved streamline and the asymmetric distribution of the elastic force. The Newtonian sheath flow was utilized to squeeze microparticles to the side wall with sharp corners at the inlet. Particles were subjected to inertial forces, elastic force and viscous drag force, all of which pointed to the straight wall side. Stronger forces were exerted on larger particles, leading to size-dependent migration of particles across the interface between the Newtonian and the viscoelastic fluids. The influence of the flow rate ratio on the particle separation was also studied. The results show that the sharp corners and the co-flowing fluid system significantly enhanced particle lateral migration, achieving complete particle separation at a low flow rate and in a short channel length. The particle separation efficiency was further increased at a higher flow rate ratio (sheath flow/sample flow). With a simple structure and small footprint, this device has great potential to be used in a variety of particle separation processes for lab-on-a-chip applications.

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Section: Resultsmentioning

confidence: 99%

Continuous elasto-inertial separation of microparticles using a co-flowing Newtonian-viscoelastic fluid system

Fan¹,

Zhao²,

Wu³

et al. 2019

J. Micromech. Microeng.

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Inertial focusing of small particles in oscillatory channel flows

Cui,

Wang,

Wang

et al. 2024

International Journal of Mechanical Sciences

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Experimental and numerical study of the effect of the channel curvature angle on inertial focusing in curvilinear microchannels

Ince

Turhan

Çadırcı

et al. 2022

Journal of Applied Physics

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Passive cell separation methods have attracted great attention due to their superiority over the other methods stemming from their easy fabrication, precise manipulation, cost-effectiveness, sensitivity, and simplicity. The fluid inertia in these methods is the main factor that is affected by the channel design; thus, the channel design parameters should be chosen accordingly. Even though all channel design parameters are well addressed in inertial microfluidics, the curvature angle of the channel has not yet been extensively studied. In this study, three different curvilinear microchannels with curvature angles of 180°, 210°, and 270° were designed, keeping all other remaining parameters the same. The focusing ability of the fluorescent polystyrene microparticles with diameters of 1.1, 3.3, and 9.9 μm was investigated both experimentally and numerically to understand focusing efficiency affected by the curvature angle of the microchannel. The first set of experiments was to determine the effect of the channel curvature and indicated the favorable design as channel C, which showed focusing qualities of 0.85 and 0.92 for 9.9 μm particles at volumetric concentrations of 2% and 5%, respectively. The remaining set of experiments and CFD simulations were conducted to observe the interaction of 3.3 and 9.9 μm particles and reveal the distortion of the focusing line and particulate phase contours for 9.9 μm particles at the flow rates between 0.3 and 0.7 ml/min, which was further confirmed by enriched mixtures containing 1.1, 3.3, and 9.9 μm particles. The study showed that mixtures comprising low diameter particles could not satisfy the focusing criteria, which emphasized the importance of an appropriate particle size and concentration for a single focus line. On the other hand, it was shown that geometric features of the microchannel such as the hydraulic diameter and the curvature angle together with the particle size determine the focusing quality both experimentally and numerically. To sum up, the increment of the channel curvature angle is a determining factor for particle focusing, and a single focusing line was observed on the particles maintaining the focusing criteria even in many particle conditions. While the focusing quality of the particles was reduced by multi-particle interactions, they were proven to be separable achieving the appropriate concentration ratio.

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Experimental and numerical investigation on particle–particle interaction of multi-particle separation in an alternating and repetitive microchannel

Cited by 4 publications

References 28 publications

Continuous elasto-inertial separation of microparticles using a co-flowing Newtonian-viscoelastic fluid system

Continuous elasto-inertial separation of microparticles using a co-flowing Newtonian-viscoelastic fluid system

Inertial focusing of small particles in oscillatory channel flows

Experimental and numerical study of the effect of the channel curvature angle on inertial focusing in curvilinear microchannels

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