The objective of the presented work is to perform numerical and experimental studies on compressor stators. This paper presents the modification of a baseline stator design using numerical optimization resulting in a new 3D stator. The Rolls Royce in-house compressible flow solver HYDRA was employed to predict the 3D flow, solving the steady RANS equations with the Spalart-Allmaras turbulence model, and its corresponding discrete adjoint solver. The performance gradients with respect to the input design parameters were used to optimize the stator blade with respect to the total pressure loss over a prescribed incidence range, while additionally minimizing the flow deviation from the axial direction at the stator exit. Non-uniform profile boundary conditions, being derived from the experimental measurements, have been defined at the inlet of the CFD domain. The presented results show a remarkable decrease in the axial exit flow angle deviation and a minor decrease in the total pressure loss. Experiments were conducted on two compressor blade sets investigating the three-dimensional flow in an annular compressor stator cascade. Comparing the baseline flow of the 42° turning stator shows that the optimized stator design minimizes the secondary flow phenomena. The experimental investigation discusses the impact of steady flow conditions on each stator design while focusing on the comparison of the 3D optimized design to the baseline case. The flow conditions were investigated using five-hole probe pressure measurements in the wake of the blades. Furthermore, oil-flow visualization was applied to characterize flow phenomena. These experimental results are compared with the CFD calculations.