This study investigated the air distribution and contaminant transport in aircraft cabins with gaspers by using computational fluid dynamics (CFD). If the detailed gasper geometry were used in the CFD simulations, the grid number would be unacceptably high. To reduce the grid number, this investigation proposed a method for simplifying the gasper geometry. The method was then validated by two sets of experimental data obtained from a cabin mockup and a real aircraft cabin. It was found that for the cabin mockup, the CFD simulation with the simplified gasper model reduced the grid number from 1.58 to 0.3 million and the computing cost from 2 days to 1 hour without compromising the accuracy. In the five-row economyclass cabin of the MD-82 airplane, the CFD simulation with the simplified gasper model was acceptable in predicting the distribution of air velocity, air temperature, and contaminant concentration.