Experimental and theoretical approach to cationic drug-anionic gemini surfactant systems in aqueous medium

Noori, Sahar; Naqvi, Andleeb Z.; Ansari, Wajid Husain; Kabir-ud-Din, †

doi:10.1016/j.colsurfb.2013.11.023

Cited by 12 publications

(9 citation statements)

References 55 publications

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“…Micellar solubilization is one approach for the improvement of solubility of hydrophobic drugs [ 72 ]. It is known that the incorporation of poorly water-soluble drugs in the nonpolar core of micelles may increase solubility, stability, and bioavailability [ 73 – 75 ]. Importantly, amphiphilic molecules and drugs can form mixed assemblies that would result in changing in the micellization process [ 66 ].…”

Section: Resultsmentioning

confidence: 99%

Nanoscale isoindigo-carriers: self-assembly and tunable properties

Pashirova

Богданов

Musin

et al. 2017

Beilstein J. Nanotechnol.

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Over the last decade isoindigo derivatives have attracted much attention due to their high potential in pharmacy and in the chemistry of materials. In addition, isoindigo derivatives can be modified to form supramolecular structures with tunable morphologies for the use in drug delivery. Amphiphilic long-chain dialkylated isoindigos have the ability to form stable solid nanoparticles via a simple nanoprecipitation technique. Their self-assembly was investigated using tensiometry, dynamic light scattering, spectrophotometry, and fluorometry. The critical association concentrations and aggregate sizes were measured. The hydrophilic–lipophilic balance of alkylated isoindigo derivatives strongly influences aggregate morphology. In the case of short-chain dialkylated isoindigo derivatives, supramolecular polymers of 200 to 700 nm were formed. For long-chain dialkylated isoindigo derivatives, micellar aggregates of 100 to 200 nm were observed. Using micellar surfactant water-soluble forms of monosubstituted 1-hexadecylisoindigo as well as 1,1′-dimethylisoindigo were prepared for the first time. The formation of mixed micellar structures of different types in micellar anionic surfactant solutions (sodium dodecyl sulfate) was determined. These findings are of practical importance and are of potential interest for the design of drug delivery systems and new nanomaterials.

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Section: Resultsmentioning

confidence: 99%

Nanoscale isoindigo-carriers: self-assembly and tunable properties

Pashirova

Богданов

Musin

et al. 2017

Beilstein J. Nanotechnol.

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“…Similarly Wajid et al [34] have also studied the interactions between amphiphilic drug amitriptyline hydrochloride (AMT) and three anionic gemini surfactants.…”

Section: Micellar Parametersmentioning

confidence: 98%

“…There are many models which can be employed to determine micellar mole fractions and interaction parameter but all the models give more or less similar trends in micellar mole fractions and interaction parameters. However, Rubingh's model has an advantage: it is much simpler than the other models and is still widely used [34,35] …”

Section: Micellar Parametersmentioning

confidence: 99%

Effect of surfactant head group on micellization and morphological transitions in drug-Surfactant catanionic mixture: A multi-technique approach

Vashishat

Chabba

Mahajan

2016

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…Due to this poor availability, a large quantity of drugs is required to complete the therapy. As a result, accumulation of drug at non-target sites increases the harmful side effects [ 9 ]. Surfactants can act as a delivery agent that not only solubilizes the drug but also raises the bioavailability of drug molecules.…”

Section: Introductionmentioning

confidence: 99%

Mixed Micellization and Spectroscopic Studies of Anti-Allergic Drug and Non-Ionic Surfactant in the Presence of Ionic Liquid

2021

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In drug delivery, surfactants are used to reduce side effects and to increase drug efficiency. The present work aimed to study the interaction of diphenhydramine hydrochloride (anti-allergic drug) with TX–45 (non-ionic surfactant) in the absence and presence of ionic liquid (1-hexyl-3-methylimidazolium chloride). The physicochemical parameters were estimated by the surface tension measurement. Various theoretical models (Clint, Rubingh, Motomura, and Maeda) were applied to determine the attractive behavior between drug and surfactant mixtures at the surface and in bulk. The drug and surfactant mixtures exhibit synergistic behavior in the absence and presence of ionic liquid. Several energetic parameters were also estimated with the assistance of regular solution approximation and pseudo phase separation model that indicate micelle formation and adsorption of surfactant at the surface is thermodynamically advantageous. The morphology of pure and mixture of amphiphiles has been estimated by the Tanford and Israelachvili theories. UV-visible spectroscopy was used to quantify the attractive behavior of the drug with surfactant with the help of a binding constant (K).

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Experimental and theoretical approach to cationic drug-anionic gemini surfactant systems in aqueous medium

Cited by 12 publications

References 55 publications

Nanoscale isoindigo-carriers: self-assembly and tunable properties

Nanoscale isoindigo-carriers: self-assembly and tunable properties

Effect of surfactant head group on micellization and morphological transitions in drug-Surfactant catanionic mixture: A multi-technique approach

Mixed Micellization and Spectroscopic Studies of Anti-Allergic Drug and Non-Ionic Surfactant in the Presence of Ionic Liquid

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