Experimental and theoretical investigation of drug loading to silica alcogels

Ülker, Zeynep; Erkey, Can

doi:10.1016/j.supflu.2015.06.025

Cited by 9 publications

(1 citation statement)

References 24 publications

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“…These properties include high specific surface area, high porosity along with low density, high sorption capacity and, most importantly, biocompatibility, which guarantees complete safety for humans [11]. Of particular interest is the use of organic aerogels in the form of particles as drug delivery systems, since the impregnation of various active substances in aerogels allows obtaining compositions with improved pharmacokinetic properties, for example, with improved bioavailability, fast or, conversely, slow release of the active substance from the pores of the aerogel [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Alginate-Based Aerogel Particles as Drug Delivery Systems: Investigation of the Supercritical Adsorption and In Vitro Evaluations

Lovskaya

Menshutina

2020

Materials

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The present work focuses on the preparation of alginate-based aerogels in the form of particles for their further study as potential drug delivery systems (solid dosage forms). The dripping method was used to prepare certain gel particles, and supercritical drying was used to obtain final alginate-based aerogel particles. Three model active substances (ketoprofen, nimesulide, loratadine) were impregnated into the obtained aerogels using the supercritical adsorption process. Using the method of X-ray analysis, it was shown that the in the obtained drug-loaded aerogels the corresponding active substances are in an amorphous state, and the stability of this state after six months of storage is confirmed. In vitro dissolution tests for obtained drug-loaded aerogels was performed. For each sample, an appropriate dissolution medium (with certain pH) was determined. In vitro investigations showed the increasing of the release rate for all model active substances. Time was required to release and dissolve 50% of the active drug from drug-loaded aerogels (T1/2), reduced in comparison with pure active drugs in crystalline form. Obtained results provide insight into the application of alginate-based aerogel particles as a drug delivery system to improve pharmacokinetic properties of certain active drugs.

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Section: Introductionmentioning

confidence: 99%

Alginate-Based Aerogel Particles as Drug Delivery Systems: Investigation of the Supercritical Adsorption and In Vitro Evaluations

Lovskaya

Menshutina

2020

Materials

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Pharmaceutical Applications of Aerogels

Smirnova,

García-González,

Gurikov

2023

Springer Handbooks

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Biodegradable polysaccharide aerogels based on tragacanth and alginate as novel drug delivery systems

Al-barudi,

Sinani,

Ulker

2024

J Sol-Gel Sci Technol

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Tragacanth, an anionic polysaccharide, is a natural material widely investigated for the synthesis of aerogels as drug delivery vehicles. Its biocompatibility, biodegradability, and affordability are all key features for its use in pharmaceutical applications. In this study, tragacanth and tragacanth alginate composite aerogels were prepared using the sol-gel technique followed by supercritical drying. Paracetamol was selected as a model drug for drug loading and release studies owing to its high solubility in ethanol and low solubility in supercritical carbon dioxide. The paracetamol loading into the aerogel pores was confirmed by infrared spectroscopy (IR) and x-ray diffraction (XRD) spectra of the resulting samples. Scanning electron microscopy (SEM) images showed that all aerogels were porous with a macroporous-mesoporous network. Due to the high porosity of the prepared aerogels, a loading of 99 wt% (mg drug/mg aerogel) for tragacanth and 114 wt% (mg drug/mg aerogel) for composite aerogels was achieved. Moreover, the release rate of the drug could be modified by manipulating the aerogel composition. Tragacanth aerogels had a faster release rate, while the addition of alginate prolonged the release rate of the model drug. Various empirical release models were investigated and the release rate was found to follow the Korsmeyer-Peppas (Power Law) model suggesting a diffusion-based release kinetics. Based on the results, the feasibility of utilizing tragacanth for the preparation of drug-loaded aerogels was shown. Graphical Abstract

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Experimental and theoretical investigation of drug loading to silica alcogels

Cited by 9 publications

References 24 publications

Alginate-Based Aerogel Particles as Drug Delivery Systems: Investigation of the Supercritical Adsorption and In Vitro Evaluations

Alginate-Based Aerogel Particles as Drug Delivery Systems: Investigation of the Supercritical Adsorption and In Vitro Evaluations

Pharmaceutical Applications of Aerogels

Biodegradable polysaccharide aerogels based on tragacanth and alginate as novel drug delivery systems

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