Experimental and theoretical studies of pegylated-β-cyclodextrin: A step forward to understand its tunable self-aggregation abilities

Rincón-López, Juliana; Ramírez-Rodríguez, Norma J.; Luviano, Alberto S.; Costas, Marı́a Eugenia; López-Cervantes, José L.; García-Figueroa, Arturo A.; Domínguez, Héctor; Mendoza‐Cruz, Rubén; Guadarrama, Patricia; López-Morales, Salvador; Rojas-Aguirre, Yareli

doi:10.1016/j.jddst.2021.102975

Cited by 4 publications

(1 citation statement)

References 56 publications

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“…Water molecules inside the CD that are not energetically favored are readily substituted by hydrophobic molecules (or regions of molecules), such as surfactants or drugs. This host–guest interaction of molecules are called inclusion complexes (ICs), which are of great interest in many areas, including pharmaceutics as drug delivery carriers. − …”

Section: Introductionmentioning

confidence: 99%

High Interfacial Viscoelasticity of Aqueous Mixed Dodecyltrimethylammonium Bromide–Sodium Dodecyl Sulfate Surfactants Forming Inclusion Complexes with α-Cyclodextrin

Luviano

Costas

2023

Langmuir

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Mixtures of anionic−cationic surfactants have shown high synergistic effects in the bulk solution and at the liquid/air interface. These studies have been limited to a reduced concentration range, where there is no formation of aggregates or precipitates. The addition of host molecules, such as cyclodextrins, to these systems reduces the effects of precipitation by forming inclusion complexes and also modifies the values of other surfactant properties, like the Krafft temperature and the critical aggregation concentration (CAC). We studied the interfacial synergistic effects promoted by electrostatic interactions, using the Rosen model to calculate an interaction parameter for mixtures of sodium dodecyl sulfate (SDS) and dodecyltrimethylammonium bromide (DTAB) in the presence of α-cyclodextrin (αCD), in aqueous solutions. We measured the CAC of SDS−DTAB−αCD mixtures using a pendant drop tensiometer, with the αCD concentration fixed at 10 mM and at 283.15 K. We performed rheological measurements on the mixtures where the surfactant total concentration is fixed below the measured CAC, varying the αCD concentration and temperature. We found that the dilatational modulus shows a clear correlation with the interaction parameter. It appears that the attractive interactions within the film are those due to the inclusion complexes formed by two αCD and one surfactant molecule, which according to the previous studies, is the dominant species in both the bulk and liquid/air interface. The synergistic effect observed here for SDS−DTAB surfactant mixtures with αCD can be applied to systems and processes (drop emission, drug delivery methods, stabilization of viral capsids and bacterial membranes, and emulsification) where interfacial processes require specific viscoelastic properties.

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Section: Introductionmentioning

confidence: 99%

High Interfacial Viscoelasticity of Aqueous Mixed Dodecyltrimethylammonium Bromide–Sodium Dodecyl Sulfate Surfactants Forming Inclusion Complexes with α-Cyclodextrin

Luviano

Costas

2023

Langmuir

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Cyclodextrins and derivatives in drug delivery: New developments, relevant clinical trials, and advanced products

Kali,

Haddadzadegan,

Bernkop-Schnürch

2024

Carbohydrate Polymers

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Exploring In Vitro Biological Cellular Responses of Pegylated β-Cyclodextrins

et al. 2022

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βCDPEG5 and βCDPEG2 are two derivatives comprising seven PEG linear chains of 5 and 2 kDa, respectively, conjugated to βCD. As βCDPEGs display different physicochemical properties than their precursors, they could also trigger distinct cellular responses. To investigate the biological behavior of βCDPEGs in comparison to their parent compounds, we performed broad toxicological assays on RAW 264.7 macrophages, MC3T3-E1 osteoblasts, and MDCK cells. By analyzing ROS and NO2− overproduction in macrophages, we found that βCDPEGs induced a moderate stress response without affecting cell viability. Although MC3T3-E1 osteoblasts were more sensitive than MDCK cells to βCDPEGs and the parent compounds, a similar pattern was observed: the effect of βCDPEG5 on cell viability and cell cycle progression was larger than that of βCDPEG2; PEG2 affected cell viability and cell cycle more than βCDPEG2; cell post-treatment recovery was favorable in all cases, and the compounds had similar behaviors regarding ROS generation. The effect on MDCK cell migration followed a similar pattern. In contrast, for osteoblasts, the interference of βCDPEG5 with cell migration was smaller than that of βCDPEG2; likewise, the effect of PEG2 was shorter than its conjugate. Overall, the covalent conjugation of βCD and PEGs, particularly to yield βCDPEG2, improved the biocompatibility profile, evidencing that a favorable biological response can be tuned through a thoughtful combination of materials. Moreover, this is the first time that an in vitro evaluation of βCD and PEG has been presented for MC3T3-E1 and MDCK cells, thus providing valuable knowledge for designing biocompatible nanomaterials constructed from βCD and PEGs.

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Experimental and theoretical studies of pegylated-β-cyclodextrin: A step forward to understand its tunable self-aggregation abilities

Cited by 4 publications

References 56 publications

High Interfacial Viscoelasticity of Aqueous Mixed Dodecyltrimethylammonium Bromide–Sodium Dodecyl Sulfate Surfactants Forming Inclusion Complexes with α-Cyclodextrin

High Interfacial Viscoelasticity of Aqueous Mixed Dodecyltrimethylammonium Bromide–Sodium Dodecyl Sulfate Surfactants Forming Inclusion Complexes with α-Cyclodextrin

Cyclodextrins and derivatives in drug delivery: New developments, relevant clinical trials, and advanced products

Exploring In Vitro Biological Cellular Responses of Pegylated β-Cyclodextrins

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