Experimental Aneurysms

McCune, William; Samadi, Alireza; Blades, Brian; Washington, .

doi:10.1097/00000658-195308000-00007

Cited by 31 publications

(8 citation statements)

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“…13 John Hunter was the first person to establish the animal model of true aneurysm. From then on, a variety of techniques have been reported for the production of experimental true aneurysm and their methodology can be divided into three categories: 1) Aneurysms induced by simulating etiological factors thought to initiate aneurysms in man, 14,15 2) aneurysms resulting from injuring the arterial wall mechanically 13,16 or by use of toxic materials, [17][18][19][20][21][22] 3) aneurysms resulting from grafting a venous pouch onto the artery. This technique was initially described by German and Black, 16 and improved by Varsos.…”

Section: Discussionmentioning

confidence: 99%

Production of animal model of traumatic pseudoaneurysm

Sun¹,

Sizhao

Chen

et al. 1998

Microsurgery

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Three microsurgical techniques, i.e., electric cauterized vein patch (ECVP), electric cauterized vein segment (ECVS), and electric cauterized muscular cavity (ECMC), were employed to produce an ideal animal model of traumatic pseudoaneurysm (TPA). In this paper, 108 cases of TPAs were produced in rabbit femoral arteries. The successful rates of these microsurgical techniques, proved by angiography, autopsy in vivo, and histological examination, were 5.5, 16.7, and 88.9%, respectively. The successful rate of ECMC, with the merits of simple operation, a narrow neck but giant size of TPA which rarely ruptured, and the pulsatile mass occurring as early as 4 to 11 days after operation, was much higher than that of ECVP and ECVS (P < 0.01). By this reliable method of ECMC, the pathogenesis of TPA was observed as the following: the arterial wall was injured and partly ruptured, then the escaped blood was confined by fibrous connective tissue near the arterial opening. As a result, a located hematoma without any pulsatile mass and vascular systolic murmur formed. When a cavity occurred in the hematoma a few days later it gradually enlarged till the clot which plugged the arterial opening became so thin that arterial blood flowed into the cavity to form a pulsating hematoma. So, a pulsatile mass with vascular systolic murmur can be observed.

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Section: Discussionmentioning

confidence: 99%

Production of animal model of traumatic pseudoaneurysm

Sun¹,

Sizhao

Chen

et al. 1998

Microsurgery

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“…Previous attempts involved the use of various compounds including a nitrogen mustard and cyanoacrylate, in order to degenerate the arterial walls, for example, [47–49], but failed to induce CAs with similar pathological characteristics to human ones.…”

Section: Animal Models Of Ca Induced By Increased Hemodynamicsmentioning

confidence: 99%

The Development and the Use of Experimental Animal Models to Study the Underlying Mechanisms of CA Formation

Aoki

Nakagawa

2010

BioMed Research International

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Cerebral aneurysms (CAs) have a high prevalence and can cause a lethal subarachnoid hemorrhage. Currently, CAs can only be treated with invasive surgical procedures. To unravel the underlying mechanisms of CA formation and to develop new therapeutic drugs for CAs, animal models of CA have been established, modified, and analyzed. Experimental findings from these models have clarified some of the potential mechanisms of CA formation, especially the relationship between hemodynamic stress and chronic inflammation. Increased hemodynamic stress acting at the site of bifurcation of cerebral arteries triggers an inflammatory response mediated by various proinflammatory molecules in arterial walls, inducing pathological changes in the models similar to those observed in the walls of human CAs. Findings from animal studies have provided new insights into CA formation and may contribute to the development of new therapeutic drugs for CAs.

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“…One group noted that rats fed a diet of 50% sweet peas developed skeletal deformities and aortic aneurysms [62]. Another group injected nitrogen mustard into the aortic adventitia of dogs to create aneurysms [63]. Surgical excision of the adventitia and chemical treatment of the aorta was also attempted [64].…”

Section: Abdominal Aortic Aneurysm Modelsmentioning

confidence: 99%