Experimental Animal Investigations with Rifampicin on the Question of its Influence on the Vestibular System and its Period of Retention in the Perilymph of the Inner Ear

Felgenhauer, F; Lagler, F

doi:10.1159/000386839

Cited by 3 publications

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“…Routine histological examination of the inner ear was negative. FELGENHAUER & LAGLER (1970) found no effects on the vestibular system of "mixed-bred'' rabbits, given high doses of RMP for five weeks. The concentration of RMP in the perilymph of guinea pigs was low and of short duration after a single oral dose.…”

Section: Discussionmentioning

confidence: 78%

Tissue Distribution of ¹⁴C‐Rifampicin II. Accumulation in Melanin‐containing Structures

Boman¹

1975

Acta Pharmacologica et Toxicologica

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Abstrucf:The tissue distribution of 14C-rifampicin was investigated by whole body autoradiography in brown mice surviving up to 30 days after a single intravenous injection. In contrast to the findings in albino mice a long-term retention was observed in the uveal tract, the inner ear and the skin. Similar results were obtained in pigmented rats. Sections of organs from a human foetus incubated in 14C-rifampicin showed selective accumulation in the pigment epithelium of the eye. Quantitative determinations of radioactivity were performed of the blood, liver, lung, kidney and eye of mice up to 4 days after a single intravenous injection of 14C-rifampicin. A 15-fold difference was found between the pigmented and the albino eye after 4 days. The findings were interpreted as evidence for a melanin affinity of rifampicin and discussed in relation to its possible ocular and otological side effects, which seem to be mostly unverified and very infrequent even during long-term therapy. However, the accumulation of transplacentally transferred drug in the eye and the inner ear provides a further reason for restricting its use during pregnancy.

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Section: Discussionmentioning

confidence: 78%

Tissue Distribution of ¹⁴C‐Rifampicin II. Accumulation in Melanin‐containing Structures

Boman¹

1975

Acta Pharmacologica et Toxicologica

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Experimental Pharmacology and Toxicology of Antituberculosis Drugs

Tettenborn¹

1988

Antituberculosis Drugs

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Mode of Action, Biotransformation and Pharmacokinetics of Antituberculosis Drugs in Animals and Man

Iwainsky¹

1988

Antituberculosis Drugs

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Experimental Animal Investigations with Rifampicin on the Question of its Influence on the Vestibular System and its Period of Retention in the Perilymph of the Inner Ear

Cited by 3 publications

References 0 publications

Tissue Distribution of ¹⁴C‐Rifampicin II. Accumulation in Melanin‐containing Structures

Tissue Distribution of ¹⁴C‐Rifampicin II. Accumulation in Melanin‐containing Structures

Experimental Pharmacology and Toxicology of Antituberculosis Drugs

Mode of Action, Biotransformation and Pharmacokinetics of Antituberculosis Drugs in Animals and Man

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Experimental Animal Investigations with Rifampicin on the Question of its Influence on the Vestibular System and its Period of Retention in the Perilymph of the Inner Ear

Cited by 3 publications

References 0 publications

Tissue Distribution of 14C‐Rifampicin II. Accumulation in Melanin‐containing Structures

Tissue Distribution of 14C‐Rifampicin II. Accumulation in Melanin‐containing Structures

Experimental Pharmacology and Toxicology of Antituberculosis Drugs

Mode of Action, Biotransformation and Pharmacokinetics of Antituberculosis Drugs in Animals and Man

Contact Info

Product

Resources

About

Tissue Distribution of ¹⁴C‐Rifampicin II. Accumulation in Melanin‐containing Structures

Tissue Distribution of ¹⁴C‐Rifampicin II. Accumulation in Melanin‐containing Structures