The research provides a comparative theoretical investigation of the operational characteristics of an electric semi-truck and vehicles powered by conventional combustion engines using diesel fuel, hydrotreated vegetable oil (HVO), and methane (including biomethane) in the dual fuel configuration. The Volvo tractor units that are offered for retail in 2024, namely the Volvo FH Electric, Volvo FH500 in dual fuel configuration, and Volvo FH500TC Diesel Euro VI, were chosen for comparison. The considerations encompassed include the road tractor’s mass, energy usage, power-to-weight ratio, dynamics, ability to recharge or refuel, payload restrictions, impact on logistics expenses, compliance with regulations on drivers’ working hours, and a report on carbon dioxide emissions. The study concludes by discussing and drawing conclusions on the competitiveness of different drive types in truck tractors, specifically in relation to identifying the most suitable areas of application. Synthetic conclusions demonstrate the high effectiveness of the electric drive in urban and suburban conditions. However, vehicles equipped with internal combustion engines using renewable fuels fill the gap in energy-intensive drives in long-distance transport.