Experimental calcification in a number of species

Bridges, J. B.; McClure, John

doi:10.1007/bf02012543

Cited by 18 publications

(8 citation statements)

References 9 publications

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“…The PbC12 is thereby diluted to a concentration of 100 pg in 0.4 ml of solution. It is known that in the mouse, 100 pg of the lead salt in 0.2 ml of solution is the minimum concentration which will cause simple calcergy (Bridges and McClure, 1972). In the first experiment, the control groups 7-10 were designed to eliminate a possible dilutional effect.…”

Section: Discussionmentioning

confidence: 99%

“…T H E subcutaneous injection of a dilute solution of lead acetate in the rat is followed by calcification of the injection site (Selye, Gabbiani and Serafimov, 1964). This phenomenon has been called simple calcergy and a similar reaction occurs in other animal species including the mouse (Bridges and McClure, 1972). In the present experiments, the effect of two inhibitors of calcification, disodiuin pyrophosphate (Na2HP204) and disodium ethane-hydroxy-1 , 1diphosphonate (EHDP) on simple calcergy has been determined and the time scales of their effectiveness have been established.…”

Section: Plate LXIXmentioning

confidence: 99%

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A comparison of the inhibitory effects of disodium pyrophosphate and disodium ethane‐hydroxy‐1, 1‐diphosphonate on simple calcergy

McClure

1979

The Journal of Pathology

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Section: Discussionmentioning

confidence: 99%

Section: Plate LXIXmentioning

confidence: 99%

A comparison of the inhibitory effects of disodium pyrophosphate and disodium ethane‐hydroxy‐1, 1‐diphosphonate on simple calcergy

McClure

1979

The Journal of Pathology

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“…For this reason time integrals of body burdens of lead may well be diagnosed by determination of the lead content in bones and teeth [23][24][25][26][27][28][29][30][31], whereas momentary body burdens of lead should be derived rather from analyses of biochemical factors [32][33][34]. When lead ions are injected in the form of lead acetate, they not only interact with the calcified tissues [35,36], but they also induce ectopic calcification [37,38]. The strong capacity of lead ions to induce calcification is clearly illustrated by a case study reporting arthritis of the hip secondary to retained bullet fragments which corroded when in contact with synovial fluid [39].…”

Section: Zincmentioning

confidence: 99%

Lattice parameters and cation distribution of solid solutions of calcium and lead hydroxyapatite

Verbeeck

Lassuyt

Heijligers³

et al. 1981

Calcif Tissue Int

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Summary. Solid solutions of calcium hydroxyapatite (CaOHA) and lead hydroxyapatite (PbOHA) of the formula Ca,0.x Pbx (PO4)6 (OH)2 were prepared by coprecipitation followed by heating at 800~ in a stream of CO2-free water vapor of 1 atm. The samples were apatitic in the range 0 < x < 6 and contained lead phosphates as a second phase at higher Pb/Ca ratios. Lattice parameters and cation distribution of the apatitic samples were determined by X-ray diffraction. The lattice parameters varied linearly with x in the range considered, whereas all Pb 2+ were located in the sixfold position for cations. There was a miscibility gap in the apatite series of solid solutions in the range 1 < x < 4, whereas apatites in the range 6 < x < 10 were not stable under the conditions of preparation. It is concluded that apatites in the range 4 < x < 6 represent a minimum in the free energy of solid solutions between CaOHA and PbOHA.

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“…The reaction was called simple calcergy and its pathogenesis in the rat was determined by histochemical techniques using lead acetate as the inducing agent (Selye, Gabbiani and Serafimov, 1964). Simple calcergy was also produced in other animal species and the pathogenesis of the reaction in the mouse described by Bridges and McClure (1972). Gabbiani, Jacqmin and Richard (1966) showed that the chlorides of the rare earth elements (elements including and related to lanthanum and also known as the lanthanides) also possessed the property of inducing simple calcergy in the rat.McClure and Gardner (1976) tested a number of Selye's calcergens for a calcific reactivity in the mouse.…”

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The production of heterotopic calcification by certain chemical salts

McClure

1980

The Journal of Pathology

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The subcutaneous injection of small quantities of LaCl3 and CeCl3 was followed by calcification of the dorsal fascia in mice. The calcification reaction was shown by separate positive histochemical tests for calcium ions (the chloranilic acid reaction) and phosphate (the von Kossa reaction). The injection of cadmium chloride and stannous salts caused damage to and a positive von Kossa reaction in the fibres of the panniculus carnosus muscle. The significance and specificity of the histochemical tests was determined by X-ray microprobe analysis of tissues injected with the above salts and other salts known to cause either combined chloranilic acid and von Kossa positive reactions or isolated von Kossa positive reactions in mouse skin. The pathogenesis of the reactions produced by LaCl3, CeCl3 and KMnO4 was studied by applying histochemical tests to tissues recovered at timed intervals after injection. The reactions produced by LaCl3 and CeCl3 were similar and occurred in the dorsal fascia with positive VK reactions occurring first after 18 followed by positive CA reactions after 24 hr. The distribution of these reactions suggested a haematogenous origin for the constituent ions. The injection of KMnO4 in a much higher dose caused damage to the skin and particularly the fibres of the panniculus carnosus muscle. In contrast to the other salts, the calcific reaction occurred in association with these fibres, showing equally positive von Kossa and chloranilic acid reactions from the early stages.

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Experimental calcification in a number of species

Cited by 18 publications

References 9 publications

A comparison of the inhibitory effects of disodium pyrophosphate and disodium ethane‐hydroxy‐1, 1‐diphosphonate on simple calcergy

A comparison of the inhibitory effects of disodium pyrophosphate and disodium ethane‐hydroxy‐1, 1‐diphosphonate on simple calcergy

Lattice parameters and cation distribution of solid solutions of calcium and lead hydroxyapatite

The production of heterotopic calcification by certain chemical salts

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