EXPERIMENTAL CARDIOVASCULAR AND LUNG RESEARCH Oxidative stress and inflammatory markers – the future of heart failure diagnostics?

Abstract

Heart failure remains one of the most important problems in cardiology despite the progress in its treatment. A number of recent studies have demonstrated the relationship between the intensification of oxidative stress and chronic inflammation and the severity of left ventricular dysfunction, development of heart failure symptoms, and prediction of future cardiac events. Early detection of changes developing in the heart is key in improving the treatment's effectiveness. It appears that determining specific, sensitive biomarkers reflecting the complex pathophysiology of heart failure and using them to detect asymptomatic cardiac alterations may become a crucial screening tool, assisting in the identification of patients requiring further diagnostic examinations. This article presents an overview of the current knowledge of the role of oxidative stress and inflammation in heart failure; it also discusses the potential role of oxidative stress and inflammatory markers as prognostic factors in heart failure that may be used in screening tests.

The Effect of Endurance Training and Purslane Seed Consumption on NF-κB and CRP in the Heart Tissue of Rats Exposed to Oxidative Damage Induced by H2O2

“…All tissues can produce the free radicals by several mechanisms. Angiotensin II, growth factors, and pro-inflammatory cytokines can contribute in ROS formation (2). Also, activation of transcription factors such as DNA damage-inducible protein 153 (GADD153), NF-κB, and growth arrest increased the expression of several genes, and the p38 mitogen-activated protein kinase (MAPK) pathway can be triggered by CRP (24,25).…”

“…Depletion of endogenous antioxidant reserves and excessive reactive oxygen species (ROS) production can induce oxidative stress (1). Free radicals can activate the transcription factor κB or nuclear protein κB (NF-κB) by stimulating metabolic pathways which, in turn, increases the expression of pro-inflammatory cytokines (2). In patients with cardiovascular disease inflammatory markers such as tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), interleukin-1 (IL-1), IL-6, IL-18, and FAS ligand are high (3).…”

Systems-wide analysis unravels the new roles of CCM signal complex (CSC)

“…Chronic inflammation has been proven to be associated with elevated oxidative stress in cardiovascular diseases 148 . A group of inflammatory factors, including CCL2, IL1α, MSN, BCL2A1 and LMAN1, were all significantly down-regulated in CCM1-KD HBMVEC cells.…”

Показники Антиоксидантного Захисту, Оксидантної Системи Та Системної Запальної Відповіді У Пацієнтів Із Хронічною Систолічною Серцевою Недостатністю Залежно Від Основних Клініко-Інструментальних Характеристик

“…У низці досліджень продемонстровано, що у патогенезі ХСН важливу роль відіграє оксидативний стрес (ОС), сутність якого полягає у дисбалансі між активністю про-та антиоксидантних систем на користь надмірного утворення активних форм кисню (вільних радикалів) з одночасним зниженням активності антиоксидантних ензимних систем захисту (Nishiyama Y. et al, 1998;Finkel T., 2003;Giordano F.J., 2005;Иванов С.Г. и соавт., 2006;Karabacak M. et al, 2014;Szczurek W. et al, 2015).…”