Experimental Chemotherapy of Melanoma

Gupta, Vicram

doi:10.1007/978-1-4613-3813-0_7

Cited by 2 publications

(1 citation statement)

References 60 publications

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“…The fact that melanoma tumors are refractary to many chemotherapeutic agents is one of the most serious problems in the chemotherapeutic treatment of melanoma. In recent times, several experiments have been conducted in the search for new antitumoral agents and combinations of agents that will enhance the resulting effect and, by the consequent reduction of dosage permitted, thereby lessen undesirable side effects (Gupta, 1984).…”

Section: Introductionmentioning

confidence: 99%

Thermochemotherapy for B16 Melanoma: Combination Therapy of Hyperthermia, Melphalan, and CCNU in Mice

Vicente

Gómez

Ochotorena

et al. 1990

Pigment Cell Research

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We studied, by means of quantitative histopathological methods, the changes that took place in B16 melanoma implanted into C57BL/6J mice after combination treatment of hyperthermia, melphalan, and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU). The studies were made on animals sacrificed on days 11, 18, and 25 after implantation. Tumors in treated animals showed a progressive delay in growth, a noticeably reduced number of metastases, and diminution of proliferative capacity. However, this treatment did not affect necrosis, stroma, capsule, or cell infiltration. Ultrastructurally, signs of cell damage were constantly present.

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Section: Introductionmentioning

confidence: 99%

Thermochemotherapy for B16 Melanoma: Combination Therapy of Hyperthermia, Melphalan, and CCNU in Mice

Vicente

Gómez

Ochotorena

et al. 1990

Pigment Cell Research

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Mucosal melanoma of the head and neck

Blatchford¹,

Koopmann

Coulthard³

1986

The Laryngoscope

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Nine cases of primary malignant melanoma of the upper respiratory tract treated at the University Hospital over the past 10 years are presented. Of the 9 cases, 6 had primary lesions located in the nasal cavity with the remaining 3 presenting in the nasopharynx, hard palate, and larynx, respectively. The authors review presenting symptoms, diagnostic evaluation, current therapeutic modalities, and clinical course in these cases. Specific cases are discussed to emphasize items of clinical or therapeutic importance.

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Experimental Chemotherapy of Melanoma

Cited by 2 publications

References 60 publications

Thermochemotherapy for B16 Melanoma: Combination Therapy of Hyperthermia, Melphalan, and CCNU in Mice

Thermochemotherapy for B16 Melanoma: Combination Therapy of Hyperthermia, Melphalan, and CCNU in Mice

Mucosal melanoma of the head and neck

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