Mucosal melanoma of the head and neck

Blatchford, Steven J.; Koopmann, Charles F.; Coulthard, Stanley W.

doi:10.1288/00005537-198609000-00001

Cited by 60 publications

(36 citation statements)

References 22 publications

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“…8,39 With a palliative intention, chemo/immunotherapy furnishes disappointing results; this may be explained in part by the fact that there is no lymphocytic infiltration around the tumor, suggesting an immunodeficiency and consecutive immunological non-respondence. In selected cases, however, cryosurgery may increase the lymphocyte activity, and this immunologic stimulation may improve the survival rates of the patients.…”

mentioning

confidence: 99%

Malignant mucosal melanoma of the head and neck — a review

Lengyel

Gilde

Remenár

et al. 2003

Pathol. Oncol. Res.

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mentioning

confidence: 99%

Malignant mucosal melanoma of the head and neck — a review

Lengyel

Gilde

Remenár

et al. 2003

Pathol. Oncol. Res.

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“…In addition, few standard systemic chemotherapies are regarded as effective. This disease is aggressive and distant metastases to the liver, lungs and brain, and regional metastases to subcutaneous tissues are the major causes of mortality in the majority of cases (10). In our institute, the 5-year survival rate for malignant melanoma of the nasal cavity is 36%.…”

Section: Discussionmentioning

confidence: 88%

A case of solitary breast metastasis from malignant melanoma of the nasal cavity

et al. 2012

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Abstract. Metastatic breast tumors are rare; however, malignant melanoma is one of the primary tumors most commonly reported to metastasize to the breast. Among these, the primary tumors typically associated with metastasis to the breast are cutaneous melanomas. We present, herein, a very rare case of solitary metastasis to the left breast from malignant melanoma of the nasal cavity, which represents less than 1% of all malignant melanomas. The patient, a 78-year-old woman, was treated using a combination of surgery and radiotherapy. In the absence of therapeutic efficacy, disease progression was very rapid. No previous studies have described malignant melanoma of the nasal cavity with solitary breast metastasis. This case report aims to increase awareness of the need to establish treatment strategies based on an understanding of the etiology and pathophysiology.

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“…The patients with metastaticcervical lymph nodes should undergo radical neck resection [18]. On the contrary, Tanaka et al [19] supported the viewpoint of Blatchford et al [20] brown, gray, purple and red. Sometimes it will be amelanotic which makes it particularly difficult to be diagnosed [2].…”

Section: Discussionmentioning

confidence: 97%

Oral Mucosa Malignant Melanoma: Clinical Features, Diagnosis, Treatment, and a Case Report

Huang¹

2015

J Dent Probl Solut

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Primary oral mucosa malignant melanoma is a rare and biologically aggressive neoplasm. It is estimated about 1~2% of all oral malignancies with the incidence increasing with age. The prognosis of oral mucosa malignant melanoma is poor with the five-year survival rate is approximately 15%. The diagnosis of oral melanoma is usually delayed because it is always asymptomatic at the beginning and it resembles the epulis, amalgam tattoo or other oral lesions. In addition, nearly a third of all oral melanoma are amelanotic and may lack a radial growth phase, which makes early and accurate diagnosis even difficult. Thus, regional and distant metastases happen more frequently. Surgery is the first choice of treatment, and clinically negative necklymph nodes with neck dissection or radiotherapy are also recommended because of the high risk of subclinical regional metastasis.In this article, we reviewed the clinical features, diagnosis, treatment, and presented a 70 y/o male who suffered from an easily bleeding lesion over right posterior palatal mucosa and gingiva who presented at hospital for help. We performed biopsy which revealed a malignant melanoma. He received supraomohyoid neck lymph node dissection, partial maxillectomy, and was reconstructed with anterior lateral thigh free fascia cutaneous flap. After surgical treatment, the patient kept regular follow-ups. The treatment outcome was good and the patient recovered with full swallowing and phonation function.components. In some cases, they may have no melanin production (amelanotic melanoma). This may also be one of the challenges to make an accurate diagnosis because melanoma can mimic a variety of undifferentiated tumors. Histological differential diagnoses included malignant lymphoma, amelanotic melanoma, spindle cell malignancies of mesenchymal tissues, and undifferentiated carcinoma. Immunohistochemical studies such as S-100 protein, HMB-45, Melan-A and Mart-1 reactivity of the tumor cells are beneficial in distinguishing such melanomas from other malignancies [4].The prognosis of oral mucosa malignant melanoma is extremely poor in relationship to its cutaneous counterpart. The 5-year survival rate is around 13%~22%. It may be resulted from delayed diagnosis and treatment, the aggressive nature of the disease, difficulty in achieving wide resection and a tendency for early hematogenous metastasis. Therapy of oral mucosa malignant melanoma is commonly based on surgical excision of the primary tumor, but it may be challenge depending on the anatomic location within the oral cavity and extent of tumor. Although melanoma is traditionally considered to be radioresistant, some authors have described improved survival and local control with postoperative radiotherapy [1,4]. In some studies, chemotherapy and immunotherapy are served as adjunctive therapies. However, there are still no guidelines or consensus in treatment of oral mucosa malignant melanoma. In this article, we reported a case of primary oral mucosa malignant melanoma over right maxillary gingi...

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Mucosal melanoma of the head and neck

Cited by 60 publications

References 22 publications

Malignant mucosal melanoma of the head and neck — a review

Malignant mucosal melanoma of the head and neck — a review

A case of solitary breast metastasis from malignant melanoma of the nasal cavity

Oral Mucosa Malignant Melanoma: Clinical Features, Diagnosis, Treatment, and a Case Report

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