Experimental Chronic Glomerulonephritis

Experimental nephritis produced by the styryl quinoline compound No. 90

“…Many of the reports are obviously descriptions of pre-existent lesions ; in addition it appears that many toxic substances can light up quiescent infections in the kidney or open the way to new infection. Clues to most of the literature can be found in the following papers ; a very critical review is much needed but will not be attempted here : uranium (Hunter, 1928 ;MacNider, 1929) : X-rays (Earlam and Bolliger, 1931): mercuric chloride (Gil y Gil, 1934; Hunter, 1929) : chromates (Oliver, 1916 ;Frandsen, 1925) : lead (Pejic', 1928) ; habu venom (Suzuki, 1919-22) : cantharidin (Frandsen, 1925) : bacteria, bacterial toxins and foreign proteins (Leiter, 1924) : acute experimental nephritis of various kinds (MacNider, 1924) : spontaneous nephritis (Leiter, 1924). Uranium and X-rays may be accepted as satisfactory agents for the production of chronic nephritis ; most of the others are doubtful or lack satisfactory confirmation.…”