Experimental Colitis Is Attenuated by Cardioprotective Diet Supplementation That Reduces Oxidative Stress, Inflammation, and Mucosal Damage

Abstract

Inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD) are multifactorial, relapsing disorders of the gastrointestinal tract. However, the etiology is still poorly understood but involves altered immune responses, epithelial dysfunction, environmental factors, and nutrition. Recently, we have shown that the diet supplement corabion has cardioprotective effects due to reduction of oxidative stress and inflammation. Since oxidative stress and inflammation are also prominent risk factors in IBD, we speculated that corabion also has beneficial effects on experimental colitis. Colitis was induced in male mice by administration of 3.5% (w/v) dextran sulfate sodium (DSS) in drinking water for a period of 3 or 7 days with or without daily gavage feeding of corabion consisting of vitamin C, vitamin E, L-arginine, and eicosapentaenoic and docosahexaenoic acid. We found that corabion administration attenuated DSS-induced colon shortening, tissue damage, and disease activity index during the onset of colitis. Mechanistically, these effects could be explained by reduced neutrophil recruitment, oxidative stress, production of proinflammatory cytokines, and internalization of the junctional proteins ZO-1 and E-cadherin leading to less edema formation. Thus, corabion may be a useful diet supplement for the management of chronic inflammatory intestinal disorders such as IBD.

Nonenzymatic Serum Antioxidant Capacity in IBD and Its Association with the Severity of Bowel Inflammation and Corticosteroids Treatment

“…Among many features of IBD, a lack of equilibrium between oxidants and antioxidants is repeatedly reported. Moreover, a potential of antioxidant therapies, which could block tissue damage and reverse natural history of IBD, is increasingly recognized [17,18,19]. In continuation of our study on oxidative stress in IBD, here, we demonstrated the diminished systemic nonenzymatic antioxidant capacity, in terms of thiol stress and reduced serum uric acid concentrations as well as total antioxidant status levels.…”

Protective effect of Gloeostereum�incarnatum on ulcerative colitis via modulation of Nrf2/NF‑κB signaling in C57BL/6 mice

“…Inflammatory bowel disease is a chronic, repetitive and non-specific gastrointestinal inflammatory disease comprising two conditions: Ulcerative colitis (UC) and Crohn's disease ( 1 ). As a chronic intestinal disease, UC produces inflammatory reactions and immune response at the colonic mucosa ( 2 ), accompanied by weight loss, diarrhea and bloody stools ( 3 ). Long-term severe colitis is known to cause colorectal cancer ( 4 ).…”

The Relationship between Serum Bilirubin and Inflammatory Bowel Disease

“…The pathogenesis of IBD is complex and remains undetermined, being thought to result from an interaction between susceptibility genes, intestinal flora disorders, environmental factors, and an excessive immune response [1–4]. Chronic colonic inflammation is associated with increased oxidative stress and disruption of the intestinal homeostasis [5, 6]. Thus, it is necessary to determine the potential mechanism of increased oxidative stress in patients with IBD [7].…”