The Relationship between Serum Bilirubin and Inflammatory Bowel Disease

Zhao, Xiaojing; Li, Linzhen; Li, Xueting; Li, Jiajia; Wang, Di; Zhang, Hongjie

doi:10.1155/2019/5256460

Cited by 35 publications

(37 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Fan et al [40], the increase in the concentration of cholesterol in rodents is a response to the production of inflammatory cytokines (mainly TNF-α and IL-1). Bilirubin is an endogenous antioxidant which promotes lipid peroxidation prevention [41]. Inoguchiet et al [42] reported that bilirubin plays a protective role against chronic inflammation.…”

Section: Biochemical Parametersmentioning

confidence: 99%

Inflammatory Correlated Response in Two Lines of Rabbit Selected Divergently for Litter Size Environmental Variability

Beloumi

Blasco

Muelas

et al. 2020

Animals

View full text Add to dashboard Cite

A divergent selection experiment for environmental variance of litter size variance was carried out in rabbits over thirteen generations. The aim of this study was to evaluate the inflammatory response in the two lines of the experiment, in order to analyse the effect of selection on susceptibility to diseases after challenging to stressful situations, such as 24 h after the first delivery. A total of 78 females were used in this study, 39 from each line. The line selected for litter size heterogeneity (the high line) showed lower white blood leukocyte count (WBC; −0.87 × 103/µL), lower percentage of basophils (−0.11%), higher concentration of TNF-α (+13.8 pg/mL), and greater concentration of CRP (+38.1 µg/mL) than the line selected for litter size homogeneity (the low line). The high line had also higher concentrations of bilirubin, cholesterol, gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) compared to the low line (difference between lines were +0.08 µmol/L, +0.14 µmol/L, +0.35 U/L and +2.4 U/L, respectively). The high line showed higher inflammatory response than the low line, in accordance with a larger susceptibility to infectious disorders. In conclusion, the line selected to increase litter size environmental variability seems to have poor capacity coping with environmental stressors. Therefore, selection for litter size environmental variability can be a useful way to improve animal welfare.

show abstract

Section: Biochemical Parametersmentioning

confidence: 99%

Inflammatory Correlated Response in Two Lines of Rabbit Selected Divergently for Litter Size Environmental Variability

Beloumi

Blasco

Muelas

et al. 2020

Animals

View full text Add to dashboard Cite

show abstract

“…Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is an idiopathic disease involving chronic inflammation of the gastrointestinal tract [1]. Although the pathogenesis of IBD has not yet been elucidated, most researchers currently believe that it is due to the interaction of genetic susceptibility, environmental factors, microbial flora imbalance, and immune disorders [2].…”

Section: Introductionmentioning

confidence: 99%

Serum Cholinesterases, a Novel Marker of Clinical Activity in Inflammatory Bowel Disease: A Retrospective Case-Control Study

Shao

Yang

et al. 2020

Mediators of Inflammation

View full text Add to dashboard Cite

Background. The aim of our study was to investigate whether serum cholinesterase (ChE) levels were associated with inflammatory bowel disease (IBD). Materials and Methods. We conducted a retrospective case-control study to clarify the relationship between serum ChE levels and IBD that included 142 patients with ulcerative colitis (UC), 60 patients with Crohn’s disease (CD), and 264 healthy controls (HCs). We used ROC curves to evaluate the diagnostic value of serum ChE levels for IBD. Results. Substantially lower serum ChE levels were detected in patients with UC than in HCs (6376 U/L versus 8418 U/L, P<0.001) and in patients with CD than in HCs (5181 U/L versus 8418 U/L, P<0.001). Additionally, patients with CD displayed significantly lower serum ChE levels than patients with UC (5181 U/L versus 6376 U/L, P<0.01). We also found that there was a negative association between serum ChE levels and the Crohn’s Disease Activity Index (CDAI) score of patients with CD (P=0.011) and the Simple Clinical Colitis Activity Index (SCCAI) score of patients with UC (P=0.018). The area under the curve (AUC) for serum ChE for the diagnosis of IBD was 0.826, and the AUCs of serum ChE for the diagnosis of CD and UC were 0.890 and 0.800, respectively. Conclusions. Serum ChE levels have important clinical significance in the diagnosis and assessment of clinical activity in patients with IBD, and the cholinergic anti-inflammatory pathway may provide new ideas for targeted treatment of IBD.

show abstract

“…Other studies have found that bilirubin has an anti-in ammatory effect. C-reactive protein (CRP) is a marker of chronic in ammation; several studies have shown that serum bilirubin levels are negatively correlated with CRP levels [23,24]. Bilirubin can also inhibit the overexpression of vascular adhesion molecules induced by the in ammatory cytokine TNF-α [25].…”

Section: Discussionmentioning

confidence: 99%

Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang

Hao

Guo

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Some studies have shown that a high level of bilirubin is a protective factor against metabolic syndrome (MS), while a high level of transaminase is a risk factor for MS. However, the existing results are inconsistent and few cohort studies have been published. Methods: Using an ambispective cohort study, 565 Kazakhs from Xinjiang, China were selected as the study subjects. The baseline serum bilirubin and transaminase levels of the subjects were divided into quartiles and the relationship between these values and the incidence of MS was analyzed. The definition of MS was based on the Joint Interim Statement (JIS) diagnostic criteria. Results: The average follow-up time for the subjects was 5.72 years. The cumulative incidence of MS was 36.11% (204 of the 565 subjects), and the incidence density was 63.10/1000 person-years. Multivariate Cox regression analysis showed that the levels of total bilirubin (TBIL) and indirect bilirubin (IBIL) were negatively correlated with the occurrence of MS, Compared to the lowest quartile level (Q1), the hazard ratios of MS the TBIL levels at the Q2-Q4 quartiles were: 0.47 (0.31-0.71), 0.53 (0.35-0.79), and 0.48 (0.32-0.72), respectively, while IBIL levels at the Q2-Q4 quartiles showed an MS hazard ratio of 0.48 (0.32-0.72), 0.54(0.36-0.81), and 0.52 (0.35-0.77), respectively, all at a 95% confidence level. However, no relationship was found between transaminase levels and the incidence of MS. Conclusion: Serum TBIL and IBIL levels were negatively correlated with the incidence of MS in a Kazakh population in China.

show abstract

The Relationship between Serum Bilirubin and Inflammatory Bowel Disease

Cited by 35 publications

References 30 publications

Inflammatory Correlated Response in Two Lines of Rabbit Selected Divergently for Litter Size Environmental Variability

Inflammatory Correlated Response in Two Lines of Rabbit Selected Divergently for Litter Size Environmental Variability

Serum Cholinesterases, a Novel Marker of Clinical Activity in Inflammatory Bowel Disease: A Retrospective Case-Control Study

Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang

Contact Info

Product

Resources

About