Experimental contributions to the study of the embryology of the vagina

Abstract

We prove the participation of Müller tubercle and Wolffian ducts in the formation of the vagina in rats, so we confirm experimentally Acién's hypothesis about the human vagina embryology.

Müllerian anomalies “without a classification”: from the didelphys-unicollis uterus to the bicervical uterus with or without septate vagina

“…Gr€ uenwald (19) affirmed that the caudal end of the M€ ullerian duct was situated inside the basal membrane of the wolffian duct, and this dependence was demonstrated clearly by the failure of the M€ ullerian duct on experimentally interrupting the wolffian duct. We think that there is no cellular contribution, because they are stained in a different way, but there is a close relationship between the wolffian and M€ ullerian ducts, which would explain why in all cases of certain vaginal anomalies (unilateral blind or atretic hemivagina, Wolff's duct lesions) there are also uterine malformations (anomalies in the M€ ullerian development) (8). Consequently, we believe that the fusion is as Gr€ uenwald (19) outlines and not as Bok and Drews (18) present it, because we have not observed light between the two fused ducts, and the diverging end of the M€ ullerian duct is practically solid when it fuses with the wolffian duct.…”

“…We interpret the subsequent evolution as follows (8). The joined portion of the M€ ullerian ducts (after medial wall reabsorption of both fused ducts) forms the uterine body (which is bicornuate in rats, because the joining is more distal).…”

“…These cases have a well characterised and proven uterine or uterovaginal anomaly according to different diagnostic procedures, including study of the surgical sample of the hysterectomy in some of the cases. In the Discussion section, we analyze the embryologic aspects and consider our experimental contributions to the study of the embryology of the vagina (8).…”

OHVIRA syndrome: a rare variant of mullerian duct anomaly

“…[ Figure 1c] This theory has been further reinforced by data published by Sánchez. 10 in his experiments with female rats using histoimmunochemistry techniques. Acein's new theory postulated that appropriate development, fusion and resorption of the separating wall between both mullerian duct seems to be induced by wolffian duct which are located on both side of the mullerian duct and act as a guide element.…”

Pediatrik Olguda Alışılmadık Bir Pelvik Ağrı Sebebi: Herlyn-Werner-Wunderlich Sendromu

“…Bu teori müllerian anomalilerine üriner sistem anomalilerinin eşlik etme mekanizmasını da açıklamaktadır. Wolf kanalı gelişiminde bir kusur mevcut ise o tarafın böbrek ve toplayıcı sistemi gelişemeyeceği gibi uterusta da füzyon anomalileri meydana gelebilmektedir (7,8). Uterus didelfis müllerian kanalların tam füzyon defekti olmakla birlikte müllerian anomalilerin yaklaşık %11'ini oluşturur (9).…”