Experimental dentigerous cysts and enamel hypoplasia: their possible significance in explaining the pathogenesis of human dentigerous cysts

Abstract

Abstraet. Cysts lined by epithelium were often found in association with tooth-germ isografts in hamster cheek pouch. They developed from odontogenic epithelium and were in close relation to the crowns of involved teeth. Cysts associated with tooth-germ isografts from 5-day-old animals (17 out of 36) commenced their formation shortly after transplantation as a result of enamel organ degen tion. Teeth assoeiated with the.se cysts often showed enamel hypoplasia. Aeeordingly. 86 teeth involved in human dentigerous eysts were examined and 43 were found to possess areas of enamel hypoplasia on their oeelusal surfaces or ineisal edges. It is suggested that the pathologieal process initiating eystic degeneration in the enamel organ was also accompanied by degeneration of ameloblasts. When tooth-germs from 2-day-old hamsters were transplanted, eystic spaces developed only after completion of enamel formation, 6 weeks following transplantation (in six out of 11 transplants), as a result of separation between the cells of the redueed enamel epithelium. Enamel hypoplasia was not a conspicuous feature. These experimental and clinical observations suggest that there may be at least two types of dentigerous cyst, perhaps with dilTerent causes, arising at diflcrent stages of tooth development.

Trauma‐induced dentigerous cyst involving an inverted impacted mesiodens: case report

“…The exact histogenesis of dentigerous cysts is unknown. It has been suggested that dentigerous cysts may be extrafollicular or intrafollicular in origin (7). Diagnosis should not be made on radiographic evidence alone but should include both macroscopic and microscopic examination of the lesion.…”

Longstanding dental pathology in Neandertals from El Sidrón (Asturias, Spain) with a probable familial basis

“…Some enamel hypoplasias may have a similar aetiology. Moreover, anomalous deciduous tooth development and or inflammation from a deciduous tooth has previously been implicated in initiating some cysts associated with permanent teeth but this has never been substantiated with certainty (Robinson, 1945;Thoma and Golman, 1960;Bartlett, et al 1973;Atkinson, 1977;Al-Talabani and Smith, 1980;Shibata et al 2004;Lustmann and Shear, 1985).…”

Dentigerous Cyst of Inflammatory Origin

“…Enamel hypoplasia is seen when a dentigerous cyst commences at an early stage of development of the involved tooth whereas in cases where the cyst originating after the completion of tooth development, enamel hypoplasia is not a significant factor. 7 In the case presented here, the unerupted premolar did not show enamel hypoplasia and it may be inferred that the cyst may have developed after the crown was fully formed.…”