Experimental Detachment of the Retina

An Experimental Model of Rhegmatogenous Retinal Detachment: Surgical Results and Glial Cell Response

“…This may explain a wide variation in the reported anatomic success, ranging from 0% to 100%. 3,6,8,20,22,25,26,32,33,37,38 This study modified existing models of RD to simulate the usual clinical presentation of human RRD. All RDs persisted for the duration of the study and many increased in size.…”

“…44 Posterior Vitreous Detachment and Lens Status. Many models of RD attempt to liquefy or remove some of the vitreous gel through chemical 5,10,32,33,37 or mechanical means, 8,11,12,20,22,25,45 but few 14 perform a complete vitrectomy or create a PVD. 4 In the pig it was possible to create a PVD, and this may have contributed to a high anatomic success rate.…”

“…7,9 -22 Not all models fully replicate the typical clinical features of RRD. Some do not rely primarily on a retinal break to create and maintain an RD [22][23][24][25][26][27][28] and many do not completely detach the posterior vitreous face from the internal limiting membrane (ILM) of the retina. 6,20,[22][23][24][25][26]29 Many models of RDs remove the crystalline lens, 4,11,14,27 yet most patients with RD are have phakic eyes.…”

“…Some do not rely primarily on a retinal break to create and maintain an RD [22][23][24][25][26][27][28] and many do not completely detach the posterior vitreous face from the internal limiting membrane (ILM) of the retina. 6,20,[22][23][24][25][26]29 Many models of RDs remove the crystalline lens, 4,11,14,27 yet most patients with RD are have phakic eyes. 30 A variety of animal species have been selected to model human RD, including rabbit, 3,6,7,[11][12][13]20,[22][23][24][25]29,31,32 cat, 27 dog, 2,26 and primate.…”

“…6,20,[22][23][24][25][26]29 Many models of RDs remove the crystalline lens, 4,11,14,27 yet most patients with RD are have phakic eyes. 30 A variety of animal species have been selected to model human RD, including rabbit, 3,6,7,[11][12][13]20,[22][23][24][25]29,31,32 cat, 27 dog, 2,26 and primate. 8,33 Individually, each of these species have important differences from human eyes in terms of either the size of the globe and crystalline lens, scleral rigidity, vitreous turgor, retinal circulation, photoreceptor type and distribution, or features such as a tapetum cellulosum.…”