Experimental Disseminated Encephalopathy in the Monkey

Ferraro, Armando; Jervis, George A.

doi:10.1001/archneurpsyc.1940.02280020003001

Cited by 79 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mechanism by which the disease is produced is still obscure. However, the regularity with which the condition occurs when Freund's adjuvant technic is used, in contrast to the difficulties in its production before adjuvants were employed (13)(14)(15), has been assumed to imply the operation of some immunological process. Adjuvants have been shown to enhance antibody production to a variety of antigens (cf.…”

mentioning

confidence: 99%

Studies on Acute Disseminated Encephalomyelitis Produced Experimentally in Rhesus Monkeys

Lumsden

Kabat

Wolf

et al. 1950

Journal of Experimental Medicine

View full text Add to dashboard Cite

1. Animals injected with emulsions of monkey brain with adjuvants show a complex pattern of antibody response as determined by complement fixation tests. 2. Organ-specific complement-fixing antibodies to constituents of brain tissue may be formed which fix complement with brain tissues of various animal species but fail to react with other organs or with rabbit placenta. 3. Antibodies may be formed to some constituent of brain other than nervous tissue. It would seem that these can be detected by the strong complement fixation given with rabbit placenta. 4. Sera from individual animals may contain antibodies to the brain or placenta constituents, to both, or to neither. Occasional individual sera show unique patterns of antibody response as determined with various additional antigens such as fetal brain, posterior pituitary, or peripheral nerves. 5. No evidence of any etiological relationship between the development of encephalomyelitis and the complement-fixing antibodies to brain demonstrable in the sera could be found. The complement-fixing antibody to the placental constituent was unrelated to the encephalomyelitis.

show abstract

mentioning

confidence: 99%

Studies on Acute Disseminated Encephalomyelitis Produced Experimentally in Rhesus Monkeys

Lumsden

Kabat

Wolf

et al. 1950

Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…Multiple sclerosis blood serum plus normal blood serum plus antigen 6 I I I I +1 I I I ±+l I +1+1 I I I I I +1 I I + I I I I I Mill I I I I I J I I I I ± I I I I + . Multiple sclerosis blood serum plus equal amount of normal blood serum plus antigen 4.…”

Section: Resultsmentioning

confidence: 99%

Antibrain Antibodies in Multiple Sclerosis

Raskin¹

1955

AMA Arch NeurPsych

View full text Add to dashboard Cite

“…Eosinophilia is not marked when the adjuvant technique is used, though it was observed by Ferraro & Jervis, Rivers & Schzventker (6) and Rivers,Sprint & Berry (4). Giant cells were described by Rivers & Schwentker (6), Ferraro & Jervis (15) and by Morrison (in one of his rabbits), i.e. in the experiments when eosinophilia was also seen.…”

Section: The Infiltrationsmentioning

confidence: 95%

Experimental Allergic Encephalo‐myelttis and Disseminated Sclerosis

T¹

1949

Allergy

View full text Add to dashboard Cite

Experimental Disseminated Encephalopathy in the Monkey

Cited by 79 publications

References 13 publications

Studies on Acute Disseminated Encephalomyelitis Produced Experimentally in Rhesus Monkeys

Studies on Acute Disseminated Encephalomyelitis Produced Experimentally in Rhesus Monkeys

Antibrain Antibodies in Multiple Sclerosis

Experimental Allergic Encephalo‐myelttis and Disseminated Sclerosis

Contact Info

Product

Resources

About