Experimental evaluation of anticonvulsant effect of human placental extract in pentylenetetrazole induced convulsions in mice

Avanthi, S; Chinnam, Pushpalatha; Rao, Gundappa S.; Kumar, G Sam Pavan; Mohsin, Mohd

doi:10.5455/2319-2003.ijbcp20131012

Cited by 2 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover; MES and PTZ induced seizures are associated with oxidative damage 21 . MES induced seizures are prevented by drugs that blocks voltage gated sodium channels.…”

Section: Discussionmentioning

confidence: 99%

“…MES induced seizures are prevented by drugs that blocks voltage gated sodium channels. Whereas the drugs that block T-type Ca +2 current in thalamus or the drugs which possess GABA A agonistic activity prevents PTZ induced convulsions 21 . The strong activity of the hexane extract of Gaisoom against PTZ induced seizures may be due to a GABA A agonistic activity of Gaisoom hexane extract.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Anticonvulsant Activity and HPLC–DAD Profiling of <i>Achillea fragrantissima</i> (Gaisoom) Extracts Growing in Saudi Arabia

Mudawi

El-wahab

Yassin

et al. 2017

AJPRHC

View full text Add to dashboard Cite

In Kingdom of Saudi Arabia Achillea fragrantissima is a fragrant, perennial herb has long been used medicinally for its analgesic properties among Rafha residents. The present study concluded that Achillea fragrantissima (Gaisoom) possess a potent anticonvulsant activity against PTZ induced seizures which may be due to GABAA agonistic activity and /or antioxidant activity. The results of the current study showed that the ethanolic extract of Gaisoom at doses of 300 mg/kg and 600 mg/kg has anticonvulsant activity in pentylenetetrazole and maximum electroshock induced seizures models on mice. The Hexane extract have protected the mice against pentylenetetrazole -induced seizures with 100% protection rate and 100% animal survival similar to the anticonvulsant drug phenobarbital. HPLC-DAD fingerprints of different fractions were also carried out to find the pharmacological active compound. The studies are in progress to isolate the compounds by HPLC technique. Supplementary studies are required to explain the exact mechanism of action by which Gaisoom act as an anticonvulsant agent.

show abstract

“…Moreover; MES and PTZ induced seizures are associated with oxidative damage 21 . MES induced seizures are prevented by drugs that blocks voltage gated sodium channels.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of Anticonvulsant Activity and HPLC–DAD Profiling of <i>Achillea fragrantissima</i> (Gaisoom) Extracts Growing in Saudi Arabia

Mudawi

El-wahab

Yassin

et al. 2017

AJPRHC

View full text Add to dashboard Cite

show abstract

Putative Prophylaxes Updated of Placenta Extract and Aloe vera as Biogenic Stimulants

Yagi

Ataka

2014

Journal of Gastroenterology and Hepatology Research

View full text Add to dashboard Cite

Gastroenterology and Hepatology Researchdation, and the possible putative prophylaxes to optimize cognitive decline in older adults with pre-diabetes symptom. Because of the diversities of placental extract and Aloe vera as biogenic stimulants, present review introduced the briefly selected authors' intentions in each topical subject. Specially, the influence of gut microbiota to host is astonishing and highlighting that the consequence of our behaviours affect not only the environment without, but also that within us. Based on geriatric and neurological viewpoint, present review highlights current therapeutic strategies of placenta extract and Aloe vera as the so-called "biogenic stimulants", aimed at producing a biological rejuvenator in placental extract and improving cognitive function via modifying the brain's insulin sensitivity in Aloe vera.

show abstract

Experimental evaluation of anticonvulsant effect of human placental extract in pentylenetetrazole induced convulsions in mice

Cited by 2 publications

References 12 publications

Evaluation of Anticonvulsant Activity and HPLC–DAD Profiling of <i>Achillea fragrantissima</i> (Gaisoom) Extracts Growing in Saudi Arabia

Evaluation of Anticonvulsant Activity and HPLC–DAD Profiling of <i>Achillea fragrantissima</i> (Gaisoom) Extracts Growing in Saudi Arabia

Putative Prophylaxes Updated of Placenta Extract and Aloe vera as Biogenic Stimulants

Contact Info

Product

Resources

About